What is globus pallidus calcification?

The basal ganglia calcifications are usually seen in the globus pallidus, the head of the caudate nucleus, and the putamen, and they commonly occur in middle-aged and elderly subjects. Brain calcifications are interpreted as incidental findings of no significance by some clinicians.

What causes mineralization in the brain?

Causes. Primary familial brain calcification is caused by mutations in one of several genes. The most commonly mutated gene is called SLC20A2, and accounts for an estimated 40 percent of cases, followed by the PDGFRB gene, which is mutated in about 10 percent of cases.

What does mineralization in the brain mean?

Comment: Mineralization in the CNS comprises either incidental multifocal microscopic deposits of mineral or secondary dystrophic calcification occurring after necrosis. Figures 1 and 2 show incidental multifocal microscopic deposits of mineral in the thalamus of rat and mouse, respectively.

What causes mineralization of the basal ganglia?

Pathological basal ganglia calcification is due to various causes, such as: metabolic disorders, infectious and genetic diseases and other. Hypoparathyroidism and pseudohypoparathyroidism are the most common causes of pathological basal ganglia calcification.

What does globus pallidus do?

The main function of the globus pallidus is to control conscious and proprioceptive movements. The GPe is the intrinsic nucleus, whereas the GPi is the output nucleus. The intrinsic nucleus acts as a relay for information. The output nucleus, primarily, sends information to the thalamus.

What is mineralization of the basal ganglia?

Basal ganglia calcification is a very rare condition that happens when calcium builds up in your brain, usually in the basal ganglia, the part of your brain that helps control movement. Other parts of your brain can be affected as well.

What are the symptoms of calcification of the brain?

Muscle cramping (dystonia), uncontrollable spasmodic irregular movements (chorea), and seizures can also occur. Occasional symptoms include sensory changes, headaches and urinary incontinence. Associated symptoms include loss of contact with reality (psychosis), mood swings and loss of acquired motor skills.

What are the functions of globus pallidus?

What is bone mineralization?

Bone mineralization, the process by which the organic bone matrix becomes filled with calcium phosphate nanocrystals, occurs in a specific, highly ordered process. The process is mediated by osteoblasts and confined to the organic osteoid matrix produced by osteoblasts.

How is bone calcification treated?

Treatments may include taking anti-inflammatory medicines and applying ice packs. If the pain doesn’t go away, your doctor may recommend surgery.