What is the principle of HLA typing?

HLA (human leukocyte antigen ) typing is a kind of genetic test. HLA typing is sometimes called HLA matching. HLA typing looks at certain factors related to the immune system. The test can help figure out if a person can safely donate bone marrow, cord blood, or an organ to someone who needs a transplant.

What is HLA typing microbiology?

The HLA type is assigned by interpreting the patterns of reactivity of dozens of sera whose specificities are known. Most antisera are obtained from donors who have been exposed by transfusion or multiple pregnancies to cells bearing foreign HLA molecules.

What is HLA typing in biochemistry?

HLA basics Human leukocyte antigen (HLA) typing is used to match patients and donors for bone marrow or cord blood transplants. HLA are proteins — or markers — found on most cells in your body. Your immune system uses these markers to recognize which cells belong in your body and which do not.

How long is HLA typing?

To start the HLA typing process: HLA typing is a blood test that requires approximately 10mL of blood. The results typically take two to three weeks to return and be processed. The blood sample can be collected in the Bone Marrow Transplant Clinic at Children’s National Health System.

What is the function of HLA?

The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation of immune responses and the selection of the T cell repertoire. A clinician’s attention is normally drawn to a system only when it malfunctions.

How do you do HLA typing test?

You and potential donors will have blood drawn or will have the inside of your cheek swabbed. The blood or cheek swab is tested in a lab to figure out your HLA type. Your HLA type will be compared to potential donors to see if there is a match. Your doctor will decide which donor has the best HLA match for you.

How does HLA testing work?

How HLA testing is done. A sample of blood is taken by inserting a needle into a vein in your arm. Sometimes a swab of cells is taken from inside of your cheek (called a buccal swab) for testing. No special preparation is needed for either method.