Can donepezil cause hypotension?
Taking an overdose of this medicine may cause convulsions (seizures) or serious effects on your heart and your breathing. Signs of overdose include increased watering of mouth, increased sweating, low blood pressure, muscle weakness, severe nausea, severe vomiting, slow heartbeat, and troubled breathing.
How does donepezil affect blood pressure?
Donepezil affects parasympathetic innervation of the myocardium. The main effect is suppression of atrioventricular node conduction. Beta-adrenergic blocking agents, such as metoprolol, block catecholamine-induced increases in heart rate, myocardial contractility and blood pressure2.
Why does donepezil cause syncope?
The cardiovascular effects of cholinesterase inhibitors are complex, but they generally augment vagal influences on the heart and promote bradycardia that can result in neurocardiogenic syncope.
What are the most common side effects of donepezil?
What side effects can this medication cause?
- loss of appetite.
- weight loss.
- frequent urination.
- difficulty controlling urination.
- muscle cramps.
Hypotension is found among people who take Donepezil, especially for people who are female, 60+ old , have been taking the drug for < 1 month, also take medication Vitamin D, and have High blood pressure.
Can donepezil cause syncope in Alzheimer’s disease?
Causes of syncope in patients with Alzheimer’s disease treated with donepezil In patients with AD treated with donepezil, a noninvasive evaluation identified a probable cause of syncope in over two-thirds of patients. Cardiovascular abnormalities were predominant.
Does donepezil cause torsade de pointes in the elderly?
In addition, donepezil is considered a drug with a known risk of QT prolongation and torsade de pointes (TdP), and geriatric patients may be at increased risk for QT prolongation.
What are the contraindications for donedonepezil?
Donepezil is contraindicated in patients with a known hypersensitivity to donepezil or to piperidine derivatives. Treatment should be initiated and supervised by a physician experienced in the diagnosis and treatment of Alzheimer’s disease and the elderly. Diagnosis should be made according to current guidelines.