How does alpha glucosidase inhibitors work?
Alpha-glucosidase inhibitors work by competitive and reversible inhibition of these intestinal enzymes. They slow the digestion of carbohydrates and delay glucose absorption. This results in a smaller and slower rise in blood glucose levels following meals, and effectively throughout the day.
How do alpha glucosidase inhibitors decrease blood glucose levels?
Alpha-glucosidase inhibitors lower blood glucose by modifying the intestinal absorption of carbohydrates. The glycemic efficacy, adverse effects, and dosing of alpha-glucosidase inhibitors will be discussed here. Other oral hypoglycemic drugs are reviewed separately.
How does the alpha-glucosidase enzyme work?
Glucosidase enzymes catalyze hydrolysis of starch to simple sugars. In humans, these enzymes aid digestion of dietary carbohydrates and starches to produce glucose for intestinal absorption, which in turn, leads to increase in blood glucose levels.
What are the side effects of alpha glucosidase inhibitors?
Adverse effects include flatulence, diarrhea, and abdominal pain from the presence of undigested carbohydrates in the lower gastrointestinal tract. These effects tend to decrease with continued use. When given alone, α-glucosidase inhibitors do not cause hypoglycemia.
When are alpha-glucosidase inhibitors used?
Alpha-glucosidase inhibitors (AGIs) are oral antidiabetic drugs used to control high blood sugar in people with type 2 diabetes mellitus (T2DM), particularly in those whose diabetes cannot be controlled by diet alone.
What is the mechanism of action of SGLT2 inhibitors?
SGLT2 inhibitors function through a novel mechanism of reducing renal tubular glucose reabsorption, producing a reduction in blood glucose without stimulating insulin release. Other benefits may include favorable effects on blood pressure and weight.
Why alpha-glucosidase is used in the treatment of diabetes mellitus?
Alpha-glucosidase inhibitors (AGIs) are drugs that inhibit the absorption of carbohydrates from the gut and may be used in the treatment of patients with type 2 diabetes or impaired glucose tolerance.
Why are alpha-glucosidase inhibitors contraindicated in inflammatory bowel disease?
Alpha-glucosidase inhibitors competitively inhibit enzymes involved in the digestion of carbohydrates. Increased gas formation in the intestines due to fermentation of the undigested carbohydrates can worsen or aggravate intestinal problems.
What is the role of glucosidase enzyme give name of any one inhibitor?
Diabetes: Acarbose, an alpha-glucosidase inhibitor, competitively and reversibly inhibits alpha-glucosidase in the intestines. This inhibition lowers the rate of glucose absorption through delayed carbohydrate digestion and extended digestion time. Acarbose may be able to prevent the development of diabetic symptoms.
What is alpha-glucosidase enzyme and what is its significance in treatment of diabetes?
Alpha-glucosidase inhibitors are pills that treat type 2 diabetes. There are two medications in this group, or class, of drugs: acarbose (Precose) and miglitol (Glyset). They help keep the amount of glucose in your blood from going up too fast after you eat.
Which of the drug is glucosidase inhibitor property?
Acarbose is an antidiabetic drug which acts by inhibiting α-amylase and α-glucosidase activities but with deleterious side effects. Gallic acid (GA) is a phenolic acid that is widespread in plant foods.
Why are angiogenesis inhibitors important?
Why Angiogenesis Inhibitors. Are important. New blood vessel formation through angiogenesis is essential to life. A constant blood supply to healthy tissues in the body such as skin, cartilage, and bone provides oxygen and nutrients for survival. In the case of cancer, tumors need a blood supply to survive.
What is the best medication for diabetes?
Biguanides.
What are acetylcholine inhibitors?
Acetylcholine release inhibitors are primarily used to treat cervical dystonia, overactive bladder, migraines, excessive sweating, and spasticity. They work by preventing muscle spasms and relaxing muscles and by blocking nerves that produce sweat.
What are alpha inhibitors?
TNF-alfa (alpha) inhibitors (TNF-alpha) are a group of medicines that suppress the body’s natural response to tumor necrosis factor (TNF), a protein produced by white blood cells that is involved in early inflammatory events.