How is antitrypsin alpha-1 tested?
Your doctor may order a screening blood test to check the level of alpha-1 antitrypsin in your body. If your levels are low, genetic testing with another blood test may be used to identify any abnormal genes.
What is a normal level of alpha-1 antitrypsin?
Most hospital laboratories report serum alpha1-antitrypsin levels in milligrams per decimeter, with a reference range of approximately 100-300 mg/dL. Levels less than 80 mg/dL suggest a significant risk for lung disease.
What is the life expectancy of someone with alpha-1?
Outlook / Prognosis Many people with Alpha-1, especially those who do not smoke, do not develop serious complications. They have a normal life expectancy. Other people may develop more serious conditions as a result of the disorder.
What is an alpha-1 antitrypsin test?
This test measures the amount of alpha-1 antitrypsin (AAT) in the blood. AAT is a protein that is made in the liver. It helps protect your lungs from damage and diseases, such as emphysema and chronic obstructive pulmonary disease (COPD). AAT is made by certain genes in your body.
Where can I get more information about alpha-1-antitrypsin deficiency?
For more information about AAT deficiency and the Alpha-1 Antitrypsin deficiency test, contact the Alpha-1 Foundation at 1-877-228-7321 or your primary care provider. [1] American Lung Association. Alpha-1 Antitrypsin Deficiency. Accessed March 30, 2018.
How many copies of alpha-1 antitrypsin are there?
Each individual inherits two copies of the gene that codes for Alpha-1 antitrypsin. It is called the protease inhibitor (SERPINA1) gene. This gene is co-dominant, which means that each SERPINA1 gene copy is responsible for producing half of the body’s Alpha-1 antitrypsin.
What is the normal range for alpha-1 antitryps?
Optimal Result: 101 – 187 mg/dL. Alpha-1 antitrypsin is a protein in the blood that protects the lungs from damage caused by activated enzymes. Alpha-1 antitryps helps to inactivate several enzymes, the most important of which is elastase. What is elastase?