Is equol a phytoestrogen?
Equol is a metabolite produced in vivo from the soy phytoestrogen daidzein by the action of gut microflora. It is known to be estrogenic, so human exposure to equol could have significant biological effects.
Is equol a isoflavone?
Equol (4′,7-isoflavandiol) is an isoflavandiol estrogen metabolized from daidzein, a type of isoflavone found in soybeans and other plant sources, by bacterial flora in the intestines. While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen.
How is equol produced?
Equol is produced from the isoflavone daidzein in the gut of humans and animals by certain bacterial biotypes; those involved might differ between individuals [30].
What gut bacteria produces equol?
The intestinal bacteria that convert daidzein to equol are present in not only the equol producers but also in the non-producers. The daidzein intake is associated with the equol production status through an increase of A. celatus and S. isoflavoniconvertens in the gut microbiota.
How does genistein function as an antioxidant?
Genistein plays an important role on recycling enzymes, which are known as body’s main antioxidant constituents. For instance, genistein induced activation of antioxidant enzymes through AMPK and PTEN pathways in prostate cancer cells (DU145).
Is s-Equol safe?
The safety data for S-equol is limited but do not suggest cause for concern, especially with regard to its effects on breast and endometrial tissue. S-equol is thought to have estrogenic activity; thus, its use is typically avoided in women with a personal of family history of breast cancer.
How do you know if you’re an equol producer?
Individuals with a plasma equol concentration of <40 nmol/l (10 μg/l) can be classified as ‘equol non-producers’ and those with concentrations >83 nmol/l (20 μg/l) classified as ‘equol producers’ (Reference Setchell, Brown and Lydeking-Olsen 6 ).
Does Lactobacillus acidophilus produce equol?
Consumption of Lactobacillus acidophilus and Bifidobacterium longum do not alter urinary equol excretion and plasma reproductive hormones in premenopausal women.
Is genistein soluble in water?
Genistein is practically insoluble in cold water; slightly soluble in hot water, hot ethanol, and hot methanol and soluble in hot 80% ethanol, hot 80% methanol, hot acetone, and pyridine. Genistein has been dissolved in DMSO and frozen in aliquots until ready for use.
What is genistein good for?
Genistein is a compound found in soy products. It has been used reduce symptoms of menopause and to help control blood glucose. It has also been used to help lower chances of prostate and breast cancer. It can be taken by eating foods like soy beans and soy milk.
Does EQUELLE work for hot flashes?
EQUELLE has been clinically validated to alleviate menopause symptoms, such as reducing the frequency of hot flashes, supporting sleep quality, alleviating mood swings, and reducing bothersome vaginal symptoms such as irritation, soreness and itching§.
Where is EQUELLE made?
gut
S-equol, the active ingredient in EQUELLE, mimics estrogen but is a plant-based, naturally-derived compound that is produced by some women in the gut in small amounts.
What is equequol?
Equol is a metabolite of daidzein, a phytoestrogen common in the human diet and abundant in soy. Intestinal bacteria in humans can reduce daidzein to equol, and can be found in normal human urine. The clinical effectiveness of soy isoflavones may be a function of the ability to biotransform soy isoflavones to the more potent estrogenic…
Does equol interact with other medications to increase the thrombogenic activities?
Etodolac may increase the thrombogenic activities of Equol. Etoricoxib may increase the thrombogenic activities of Equol. Equol may increase the thrombogenic activities of Evolocumab. The therapeutic efficacy of Exemestane can be decreased when used in combination with Equol. Equol may increase the thrombogenic activities of Fanolesomab.
What is the difference between S-equol and R-equel?
S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER. Equol is a member of hydroxyisoflavans. Equol has been used in trials studying the treatment of Breast Cancer.
Does equol affect the efficacy of sacituzumab?
Equol may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy. Equol may increase the thrombogenic activities of Sacituzumab govitecan. Equol may increase the thrombogenic activities of Sarilumab.