Is Long-Evans inbred?
Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson’s disease and non-insulin dependent diabetes mellitus, respectively.
Are Sprague Dawley rats inbred?
In the rat, Sprague-Dawley and Wistar outbred stocks accounted for 86% of the total. The most widely used inbred strains were F344 and LEW, which accounted for 11% of hits.
Why do we use Sprague Dawley?
The Sprague Dawley rat is an outbred multipurpose breed of albino rat used extensively in medical research. Its main advantage is its calmness and ease of handling. These rats typically have increased tail to body length ratio compared with Wistar rats.
What are F344 N rats?
Fischer 344 (F344) rats were originally bred at Columbia University in 1920 by Curtiss and Dunning. Lewis (LEW) rats were originally developed by Margaret Lewis from the Wistar strain. The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology.
How much do Sprague Dawley rats cost?
|Age in Weeks||Quantity|
|5 to 6||$30.00|
|7 to 8||$44.00|
|9 to 10||$46.00|
Why are lab rats always white?
But getting to the original question, most lab mice are white because they are albino. They are albino from 1000+ generations of inbreeding which brings out that recessive gene. Although most lab mice are really pigmented, the tv and news crews have a tendency to only show the albino/white strains on their reports.
What is the difference between Lister hooded and Wistar rats?
In general, increased activity was observed in the basolateral amygdala, stria terminalis, and entorhinal cortex, but Wistar rats showed less pronounced neuronal activation to playback of 20-kHz sine-wave tones than Lister hooded rats. Most importantly, the pattern of activation in the PAG differed from that of Lister hooded rats.
What is the average litter size of a Sprague Dawley rat?
The average litter size of the Sprague Dawley rat is 11.0. These rats typically have a longer tail in proportion to their body length than Wistar rats. They were involved in the Séralini affair, where the herbicide RoundUp was claimed to increase the occurrence of tumor in these rats.
What is a Wistar rat?
The Wistar rat is an outbred albino rat. This breed was developed at the Wistar Institute in 1906 for use in biological and medical research, and is notably the first rat developed to serve as a model organism at a time when laboratories primarily used the house mouse ( Mus musculus ).
Where is neural activity enhanced in Lister hooded rats?
In Lister hooded rats, where playback of 20-kHz tones increased locomotor activity, enhanced neuronal activity was preferentially detected in the dorsal region of the rostral and caudal PAG.