What are the 3 types of NSCLC?
There are three main subtypes of non-small cell lung cancer (NSCLC), including the following:
- Squamous cell carcinoma (25% of lung cancers).
- Adenocarcinoma (40% of lung cancers).
- Large cell carcinoma (10% of lung cancers).
Which is more aggressive SCLC or NSCLC?
Small cell cancers vary , depending on the expression of specific genes. Some types are more aggressive than others, but generally, small cell cancer is more aggressive than non-small cell lung cancer.
What is Nonsquamous NSCLC?
NSCLC includes non—small cell carcinoma not otherwise specified (<5%), SCC (25%- 30%), and nonsquamous carcinoma (adenocarcinoma, large cell, and undifferentiated carcinoma; 70%-75%) (FIGURE 1). 4,5. A recent systematic review reported that the median age at diagnosis of advanced NSCLC ranged between 59 and 68 years.
What are miRNAs used for?
MiRNAs are small non-coding RNAs with a length of approximately 19–25 nt, which can regulate various target genes. MiRNAs are involved in the regulation of a variety of biological processes, such as cell cycle, differentiation, proliferation, apoptosis, stress tolerance, energy metabolism, and immune response .
What is first line treatment for NSCLC?
In advanced NSCLC, chemotherapy is recommended as first-line treatment in patients with good performance status. Treatment objectives are survival, quality of life and symptom control improvement. Cisplatin-based chemotherapy with one of the effective regimens should be used.
Who is NSCLC?
NSCLC is generally regarded as a disease of the elderly, but a third of patients are diagnosed before the age of 65 years. 16 Surgery and adjuvant chemotherapy are important contributors to cure for early stage disease.
Is Nsclc squamous or nonsquamous?
Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers (2), and can be subclassified as squamous (∼30%) or non-squamous (∼70%; includes adenocarcinoma and large cell histologies) histological types (3).
Is mirna-21 overexpressed in cancer?
MiRNA-21 has been shown to be overexpressed in multiple malignancies including pancreatic cancer [ 10, 11 ], esophageal cancer [ 12 ], lung cancer [ 13 ], and colon cancer [ 14 ]. This miRNA has been linked to tumor aggression and carcinogenesis, in part, by preventing apoptosis and, thus, functioning as an oncogene [ 15, 16 ].
What is MicroRNA-21 (miR-21)?
MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC). Clin Chim Acta. 2010;411:846–852.
Is mirna-21 a prognostic factor for acute myeloid leukemia?
Multivariate Cox regression analysis showed that miRNA-21 was an independent prognostic factor for patients. Down-regulation of miRNA-21 inhibited proliferation and cell cycle progress of A549 cells and sensitized cells to radiation. Decreased miRNA-21 expression promoted the apoptosis of A549 cells induced by irradiation.
Is miR-21 overexpression associated with EGFR-TKI resistance in non-small cell lung cancer?
Li B, Ren S, Li X, et al. miR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer. Lung Cancer. 2014;83:146–153.