What are the possible complications of TPN?

What are the possible complications of TPN?

Possible complications associated with TPN include:

  • Dehydration and electrolyte Imbalances.
  • Thrombosis (blood clots)
  • Hyperglycemia (high blood sugars)
  • Hypoglycemia (low blood sugars)
  • Infection.
  • Liver Failure.
  • Micronutrient deficiencies (vitamin and minerals)

What is a complication of long term use of TPN?

Bone disease (osteoporosis) TPN-induced liver damage or liver failure. TPN-induced liver failure occurs more often in children than adults. Some people who receive long-term TPN may develop social problems because TPN can severely limit their everyday activities.

What is an example of metabolic complication that can occur with parenteral nutrition support?

The metabolic complications associated with PN in adult patients include hypergly- cemia, hypoglycemia, hyperlipidemia, hy- percapnia, refeeding syndrome, acid–base disturbances, liver complications, manga- nese toxicity, and metabolic bone disease.

What are the most common complications of enteral feedings and how are these complications managed?

Complications of enteral feeding. Patients with feeding tubes are at risk for such complications as aspiration, tube malpositioning or dislodgment, refeeding syndrome, medication-related complications, fluid imbalance, insertion-site infection, and agitation.

What happens if PN is infused too quickly?

In extreme cases PN can result in a hyperosmolar, hyperglycaemic non-ketotic coma. When suddenly discontinuing parenteral intake, rebound hypoglycaemia, although rare, may occur. Abnormalities in the acid-base-balance can occur due to PN and may result in significant electrolyte shifts.

What does TPN do to the liver?

One of the major causes of morbidity and mortality in patients receiving long-term total parenteral nutrition (TPN) is liver disease. Early on, there is steatosis, which can evolve to steatohepatitis and eventually to cholestasis of varying severity.

Why does parenteral nutrition cause hepatic steatosis?

We conclude that hepatic steatosis in TPN is a result of overfeeding a glucose only substrate and that fatty infiltration is independent of changes in blood hepatic enzyme concentrations.

What are the long term effects of TPN?

In brief: Short and long term. There are both short and long term complications of tpn. Short term complications include infections, and imbalance of electrolytes, fluid status and blood glucose levels. Long term TPN can result in loss of IV access and also liver injury and cirrhosis.

Why is TPN High Risk?

Patients receiving total parenteral nutrition (TPN) are at high risk for bloodstream infections ( BSI ). The notion that intravenous calories and glucose lead to hyperglycemia , which in turn contributes to BSI risk, is widely held but is unproven.

How much does TPN cost per day?

TPN is custom-made by a pharmacist, and costs about $650 per day, plus the cost of saline, heparin, plastic tubes, PICC line dressing changes and pump rental. Thankfully, our insurance covers all of this and our home health care provider delivers supplies to our home as needed.

Does TPN prolong life?

TPN is not an aproved hospice treatment because it does not promote comfort TPN can indeed prolong life. Forced nutrition i.e. forced feeding, tube feeding and other forms of artificial feeding are counter to end of life comfort because at the end of life the body is shutting down and not able to process these.

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