What does BCL6 positive mean?

What does BCL6 positive mean?

Christopher: “A positive result indicates the presence of inflammation in the uterine lining most commonly associated with endometriosis. The test measures the levels of a certain marker called BCL6 in endometrial tissue.

What is the function of BCL6?

BCL6 prevents premature activation and differentiation of GC B cells and provides an environment tolerant of the DNA breaks associated with immunoglobulin gene remodeling mechanisms involved in the production of high-affinity antibodies of different isotypes.

What is germinal center type?

Germinal centers (GC) are transient and dynamic structures that form within lymphoid follicles upon antigen challenge. 1 Antigen‐activated GC B cells undergo rapid proliferation and somatic hypermutation of their immunoglobulin variable genes in order to generate high‐affinity B‐cell receptors (BCR).

Is BCL6 an oncogene?

The BCL6 gene has long been recognized as an important oncogene in B-cell lymphoma due to its direct deregulation by promiscuous translocations that place it under control of the immunoglobulin heavy-chain locus or a variety of alternative regulatory elements (Ye et al., 1993; Chen et al., 1998).

What does high BCL6 mean?

Abnormal expression of BCL6 (> 1.4 HSCORE) was strongly associated with poor reproductive outcomes in IVF cycles. Our previous study reported that elevated expression of BCL6 is a validated biomarker for detection of endometrial inflammation and it is most commonly associated with endometriosis in women with UI (11).

What does BCL6 stand for?

B-cell lymphoma 6 protein is a protein that in humans is encoded by the BCL6 gene.

Which chromosome is BCL6?

The BCL6 gene on chromosome 3q27 encodes a 96 kDa sequence-specific transcriptional repressor protein with 6 C-terminal zinc-finger motifs and an N-terminal POZ/ZIN domain homologous to a family of zinc-finger proteins.

What is germinal Centre in lymph node?

Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer’s patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation …

What do germinal centers in lymph nodes do?

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection.

Can silent endometriosis cause miscarriage?

Whatever the mechanism may be, a study published in November 2017 in Fertility and Sterility found that women with endometriosis had nearly double the risk of miscarriage compared with women who don’t have the condition.

What is BCL6 endometriosis?

Objective. B-cell CLL/lymphoma 6 (BCL6) is a proto-oncogene that is overexpressed in the secretory endometrium of women with endometriosis. It has been postulated that BCL6 may serve as a surrogate marker for occult endometriosis, as well as a predictor of endometrial dysfunction and poor implantation.

Where is BCL6 found?

The BCL6 gene located on 3q27 is translocated in 40% of diffuse large B-cell lymphomas. Reciprocal translocations can involve a number of other chromosomal locations, including 14q32 (IGH), 2p11 (IGK), and so on, all juxtaposing to 3q27.

Does the BCL6 proto-oncogene suppress p53 in germinal-centre B cells?

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells The human proto-oncogene BCL6 encodes a BTB/POZ-zinc-finger transcriptional repressor that is necessary for germinal-centre formation and is implicated in the pathogenesis of B-cell lymphoma.

Are igμ/bcl6-translocated cells associated with germinal center markers in normal lymphoid tissues?

Igμ/BCL6-translocated cells are associated with germinal center markers in normal lymphoid tissues To further analyze the Igμ/BCL6translocation events in normal human lymphoid tissues and in circulation, we investigated the distribution of the Iμ-BCL6E2 transcripts in human lymphoid tissues and PBMCs.

Are ig/bcl6 translocations sufficient to cause malignant transformation in human B cells?

This study shows that Ig/BCL6translocations occur in germinal center–stage B cells in healthy humans, and that Ig/BCL6CTs per se are not likely sufficient to cause the malignant transformation in the context of human B cells. Introduction

Are bcl6ct cells part of the GC stage of B cell development?

The association of Ig/BCL6CT cells with GC phenotypes suggests that the CT occurs at the GC stage of B-cell development (indicating that these CT cells are the products of the GC reaction).