What is AUC ratio?
The metric for the degree of DDI in vivo is the area under the plasma concentration–time curve (AUC) ratio for the plasma concentration in the presence and absence of the inhibitor after multiple oral dosing.
What does AUC mean in pharmacokinetics?
area under the curve
In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called “area under the curve” or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
What does high AUC mean drug?
Changes in Drug Clearance vs Plasma Concentrations The AUC and Css indicate the total exposure to a drug and are usually related to the drug’s response. An increase in Cl will decrease AUC and a decrease in Cl increases AUC.
What is C max and AUC?
Abstract. In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.
What factors affect AUC?
The AUC is directly proportional to the dose when the drug follows linear kinetics. The AUC is inversely proportional to the clearance of the drug. That is, the higher the clearance, the less time the drug spends in the systemic circulation and the faster the decline in the plasma drug concentration.
What is AUC in pharmacokinetics and pharmacodynamic analysis?
Pharmacodynamics describes the interaction of drugs with target tissues. GI (more…) AUC, the area under the curve, represents the total drug exposure integrated over time and is an important parameter for both pharmacokinetic and pharmacodynamic analyses.
Is the AUC ratio unique for each drug?
The AUC ratio is not unique and characteristic for each drug if AUCpla is calculated at any time different from infinite.
How do you calculate AUC ratio?
The AUC ratio was calculated as indicated in Equation 1: (1) (AUC T 0 T last) per (AUC T 0 T last) pla being T 0 the start of the instillation and T last the last time used for the calculation of the AUC, either in peritoneum cavity or in plasma. Evaluation of the Impact of T last_pla on the AUC Ratio
What is the relationship between AUC and drug clearance?
The AUC is directly proportional to the dose when the drug follows linear kinetics. The AUC is inversely proportional to the clearance of the drug. That is, the higher the clearance, the less time the drug spends in the systemic circulation and the faster the decline in the plasma drug concentration.