What is bt474 cell line?

What is bt474 cell line?

The BT-474 line was isolated by E. Lasfargues and W.G. Coutinho from a solid, invasive ductal carcinoma of the breast. Age 60 years Ethnicity White Gender Female Karyotype. The cell line is aneuploid human female (XO usually), with most chromosome counts in the hypertetraploid range.

Who makes lapatinib?

Pharmaceutical company GlaxoSmithKline (GSK) markets the drug under the propriety names Tykerb (mostly U.S.) and Tyverb (mostly Europe and Russia).

Is lapatinib available on NHS?

Lapatinib is not routinely offered on the NHS. Your specialist team will be able to tell you if it might be of benefit and if you’ll be able to receive it. Find out more about the availability of cancer drugs. Lapatinib is usually taken in combination with other treatments such as chemotherapy or hormone therapy.

Does lapatinib cause hair loss?

Oral drugs for breast cancer, such as capecitabine (Xeloda) or lapatinib (Tykerb), may cause hair thinning versus the toxic alopecia that can be caused by some intravenous chemotherapeutic agents.

How much does trastuzumab cost?

Results. Trastuzumab costs $49,915 and $28,350 per patient treated in the adjuvant and metastatic breast cancer settings, respectively; bevacizumab costs $48,490 and $39,614 per patient treated in the metastatic lung and colorectal cancer settings, respectively.

How much does lapatinib cost?

Lapatinib is used to treat a certain type of breast cancer (HER2-positive). Learn more about this drug here. This is a brand name drug and a generic may be available. The average cost for 300 Tablet(s), 250mg each of the generic (lapatinib ditosylate) is $12,070.05.

How effective is lapatinib?

CNS objective responses to lapatinib were observed in 6% of 242 patients. In 21% of patients, 20% and more volumetric reduction was detected. It was associated with improvement of progression-free survival.

What does letrozole do to the body?

Letrozole is in a class of medications called nonsteroidal aromatase inhibitors. It works by decreasing the amount of estrogen produced by the body. This can slow or stop the growth of some types of breast cancer cells that need estrogen to grow.

What are side effects of oxaliplatin?

Side Effects

  • Diarrhea, changes in taste, mouth sores, nosebleeds, tiredness, headache, dizziness, or trouble sleeping may occur.
  • Temporary hair loss may rarely occur.
  • Oxaliplatin can sometimes affect how your nerves work (peripheral neuropathy).

How do I prepare btbt-20 cells for freezing?

BT-20 cells are negative for estrogen receptor, but do express an estrogen receptor mRNA that has deletion of exon 5. Check all containers for leakage or breakage. Remove the frozen cells from the dry ice packaging and immediately place the cells at a temperature below ­-130°C, preferably in liquid nitrogen vapor, until ready for use.

What is the pathophysiology of BT-20 cells?

A mycoplasma contaminant was discovered and eliminated early in 1972. Growth of BT-20 cells is inhibited by tumor necrosis factor alpha (TNF alpha). BT-20 cells are negative for estrogen receptor, but do express an estrogen receptor mRNA that has deletion of exon 5. Check all containers for leakage or breakage.

How do I get a certificate of analysis for BT-20 (htb-19)?

To download a certificate of analysis for BT-20 ( HTB-19 ), enter the lot number exactly as it appears on your product label or packing slip. The certificate of analysis for that lot of BT-20 ( HTB-19) is not currently available online. Complete this form to request this certificate of analysis.

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