What is CREB and how does it work in the nucleus accumbens?

What is CREB and how does it work in the nucleus accumbens?

The transcription factor cAMP response element (CRE)-binding protein (CREB) has been shown to regulate neural plasticity. Increased CREB activity in the nucleus accumbens shell decreases an animal’s responses to each of these stimuli, whereas decreased CREB activity induces an opposite phenotype.

What is CREB Signalling?

CREB as an integrative signaling molecule involved in schizophrenia. Dopamine stimulates the phosphorylation of CREB through D1R-mediated cAMP/PKA pathway or inhibits it through the D2R-mediated cAMP/PKA pathway.

Which of the following is a transcription factor that is critical in memory formation?

Hence, various results indicate that CREB is critical for memory formation.

What is the function of CREB?

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element.

How is CREB activated?

CREB proteins are activated by phosphorylation from various kinases, including PKA, and Ca2+/calmodulin-dependent protein kinases on the Serine 133 residue. When activated, CREB protein recruits other transcriptional coactivators to bind to CRE promoter 5′ upstream region.

What is the role of CREB in our memories?

The cellular transcription factor CREB (cAMP response element-binding protein) helps learning and the stabilization and retrieval of fear-based, long-term memories. This is done mainly through its expression in the hippocampus and the amygdala.

How could activating a transcription factor cause long-term cellular changes?

The transcription factors are the accessory protein. The activating factor leads to activate the transcription of DNA. Due to this, the changes of genes take place. It may severely damage the cells or long-term cellular changes.

Why are regulatory genes important?

Gene regulation is an important part of normal development. Genes are turned on and off in different patterns during development to make a brain cell look and act different from a liver cell or a muscle cell, for example. Gene regulation also allows cells to react quickly to changes in their environments.

What is a torc coactivator?

Here, we characterize a conserved family of coactivators, designated TORCs, for Transducers of Regulated CREB activity, that enhances CRE-dependent transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB.

Does the coiled-coil domain in torcs interact with CREB bZIP domains?

Remarkably, an N-terminal 56-amino acid fragment containing the highly conserved coiled-coil domain in TORCs appeared sufficient for interaction with the bZIP domain of CREB (Figure 5B).

Is the CREB transactivation domain bipartite?

The CREB transactivation domain is bipartite, consisting of kinase-inducible (KID) and constitutive (Q2) activators that function cooperatively in response to cAMP agonist Brindle et al. 1993, Quinn 1993.

Are torcs the most potent inducers of Camp?

Labow and coworkers have observed similar effects of TORCs on CREB activity (personal communication). Consistent with the tetrameric nature of these proteins, TORCS are by far the most potent inducers of cAMP-responsive genes we have observed.

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