What is ImmunoHistoChemistry in breast cancer?

What is ImmunoHistoChemistry in breast cancer?

IHC, or ImmunoHistoChemistry, is a special staining process performed on fresh or frozen breast cancer tissue removed during biopsy. IHC is used to show whether or not the cancer cells have HER2 receptors and/or hormone receptors on their surface. This information plays a critical role in treatment planning.

What is Calponin and caldesmon?

Calponin and caldesmon, constituents of smooth-muscle thin filaments, are considered to be potential modulators of smooth-muscle contraction. Both of them interact with actin and inhibit ATPase activity of smooth- and skeletal-muscle actomyosin.

Is caldesmon the same as calmodulin?

The protein caldesmon, originally isolated from smooth muscle tissue where it is the most abundant calmodulin-binding protein, has since been shown to have a wide distribution in actin- and myosin- containing cells where it is localized in sub-cellular structures concerned with motility, shape changes and exo- or endo- …

What is calponin and what does it do?

Calponin, like caldesmon, is an actin-binding protein found in appreciable quantity in a variety of smooth muscles and some nonmuscle tissues (Takahashi et al., 1986, 1988a,b; Lehman and Kaminer, 1984; Winder and Walsh, 1990 ). Evidence for a role in regulating actomyosin ATPase, although attractive, remains inconclusive at best.

What is H1 (basic) isoform calponin?

Cite this page: Pernick N. Calponin. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/stainscalponin.html. Accessed September 7th, 2021. h1 (basic) isoform is smooth muscle specific, but a late stage smooth muscle marker; described below

Which immunohistochemical studies are used in the workup of breast cancer?

An immunohistochemical study of the breast using antibodies to basal and luminal keratins, alpha-smooth muscle actin, vimentin, collagen IV and laminin. Part II: Epitheliosis and ductal carcinoma in situ. Virchows Arch A Pathol Anat Histopathol.

What is immunohistochemistry (IHC)?

Immunohistochemistry (IHC) is used to characterize intracellular proteins or various cell surfaces in all tissues.

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