What is mitogen Activated Protein kinase 3?
MAPK3 (Mitogen-Activated Protein Kinase 3) is a Protein Coding gene. Diseases associated with MAPK3 include Bile Duct Cancer and Pancreatic Adenocarcinoma. Among its related pathways are RET signaling and Activated TLR4 signalling. An important paralog of this gene is MAPK1.
What is the function of ERK?
ERK cascade plays a crucial role in multiple cellular processes such as cell proliferation, differentiation, adhesion, migration and survival. Therefore, it is essential for many physiological events including development, immunity, metabolism, and memory formation.
What type of regulatory enzyme is ERK?
ERK is a promiscuous kinase and can phosphorylate more than 100 different substrates. Therefore activation of ERK can affect a broad array of cellular functions including proliferation, survival, apoptosis, motility, transcription, metabolism and differentiation.
What is the function of MAPK1 Erk2 and MAPK3?
Select a section on the left to see content. Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF.
What does MAPKAPK5 stand for?
“MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.” Biochem. Biophys. Res. Commun. 243:492-496 (1998) [ PubMed] [ Europe PMC] [ Abstract]
How many substrates does mapk1/3 regulate?
Activated MAPK1/3 phosphorylate and regulate the activities of an ever growing pool of substrates that are estimated to comprise over 160 proteins (Yoon and Seger 2006). The majority of ERK substrates are nuclear proteins, but others are found in the cytoplasm and other organelles.
Which of the following is an essential component of the MAPK/ERK cascade?
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade.