What is plasma clearance test?
Plasma clearance (a volume per time, i.e. a flow) expresses the overall ability of the body to eliminate a drug by scaling the drug elimination rate (amount per time) by the corresponding plasma concentration level.
How is iohexol measured?
Iohexol can be measured using different methods. High performance liquid chromatography with ultraviolet detection (HPLC-UV), X-ray fluorescence (XRF) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) are certainly the most validated methods.
What do you mean by clearance?
Definition of clearance 1 : an act or process of clearing: such as. a : the removal of buildings from an area (such as a city slum) b : the act of clearing a ship at the customhouse also : the papers showing that a ship has cleared.
What affects plasma clearance?
Effect of plasma protein binding For substances that exhibit substantial plasma protein binding, clearance is generally dependent on the total concentration (free + protein-bound) and not the free concentration.
Is creatinine clearance the same as GFR?
Creatinine Clearance ( CrCl ) versus Glomerular Filtration Rate ( GFR ) Creatinine clearance ( CrCl ) is an estimate of Glomerular Filtration Rate ( GFR ); however, CrCl is slightly higher than true GFR because creatinine is secreted by the proximal tubule (in addition to being filtered by the glomerulus).
What is iohexol injection USP?
Omnipaque (iohexol injection) is a radiographic contrast medium indicated for intrathecal administration in adults including myelography (lumbar, thoracic, cervical, total columnar) and in contrast enhancement for computerized tomography (myelography, cisternography, ventriculography).
What does iohexol clearance mean?
Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate . . . et al. . .
How is iohexol plasma clearance assessed by dried blood spot testing?
We propose to simplify the plasma clearance of iohexol, a gold standard method to measure renal function, by dried blood spot (DBS) testing. Methods: We compared glomerular filtration rate (GFR) values assessed by DBS and the reference plasma analysis technique.
Is plasma and renal clearance of iohexol reproducible?
Plasma and renal clearance of iohexol—a study on the reproducibility of a method for the glomerular filtration rate . et al. . . .
How accurate is Iohexol as a GFR measurement?
In a recent review article [3], authors pooled data from seven available studies comparing iohexol (both plasma or urinary clearance) with GFR measured by inulin and calculated median bias and accuracy within 30 and 10%. For iohexol urinary clearance studies, the mean (± standard deviation) GFR, measured by inulin, was 81 ± 38 mL/min/1.73 m2.