What is QUADRAMET used for?
What is Quadramet used for? Quadramet is used to relieve bone pain in patients with multiple painful osteoblastic skeletal metastases (when cancer has spread to the bones). Osteoblastic metastases are a type of bone metastasis where new bone tissue grows rapidly.
What is samarium-153 used for?
A radioactive substance used to treat bone cancer and other cancers that have spread to the bone. Samarium Sm 153 is a radioactive form of the element samarium. It collects in bone, where it releases radiation that may kill cancer cells.
Is samarium used to treat lung cancer?
Pain begins to improve in the first week for most people and the effects can last several months. It is commonly used in lung cancer, prostate cancer, breast cancer, and osteosarcoma.
What is the half-life of samarium-153?
Samarium-153 emits medium-energy beta particles and an imageable gamma photon with a physical half-life of 46.3 hr.
What is the half-life of samarium 147?
List of isotopes
| Nuclide | Z | Half-life |
|---|---|---|
| Excitation energy | ||
| 147Sm | 62 | 1.06(2)×1011 y |
| 148Sm | 62 | 7(3)×1015 y |
| 149Sm | 62 | Observationally Stable |
What are samarium uses?
Samarium is used to dope calcium chloride crystals for use in optical lasers. It is also used in infrared absorbing glass and as a neutron absorber in nuclear reactors. Samarium oxide finds specialised use in glass and ceramics.
How is samarium-153 administered?
Sm-153 is administered in a 1.0-mCi/kg (37 MBq/kg) dose intravenously over the course of 1 minute. Approximately 50% of the dose is localized to bone. It accumulates in metastatic lesions in a 5:1 ratio compared with normal bone.
How is strontium-89 used in medicine?
Strontium chloride Sr 89 is used to help relieve the bone pain that may occur with certain kinds of cancer. The radioactive strontium is taken up in the bone cancer area and gives off radiation that helps provide relief of pain.
How effective is strontium-89?
Strontium-89 therapy is an effective palliative treatment of bone metastases from prostate cancer, with analgesic effectiveness in 80%.
Is Quadramet contraindicated for osteoblastic metastatic lesions?
QUADRAMET ® is indicated for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan. QUADRAMET ® is contraindicated in patients who have known hypersensitivity to EDTMP or similar phosphonate compounds.
What is Quadramet used to treat?
Quadramet ® is indicated for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan. Quadramet ® is contraindicated in patients who have known hypersensitivity to EDTMP or similar phosphonate compounds.
What are the side effects of Quadramet®?
In controlled studies, 7% of patients receiving 1.0 mCi/kg QUADRAMET ® (as compared to 6% of patients receiving placebo) reported a transient increase in bone pain shortly after injection (flare reaction). This was usually mild, self-limiting, and responded to analgesics.
Is Quadramet safe for babies?
If QUADRAMET ® is administered, formula feedings should be substituted for breast feedings. Safety and effectiveness in pediatric patients below the age of 16 years have not been established. Adverse events were evaluated in a total of 580 patients who received QUADRAMET ® in clinical trials.