What is surface nucleolin?

What is surface nucleolin?

Surface nucleolin serves as a low affinity receptor for HIV-1 and various growth factors that interact with its C-terminal domain containing nine repeats of the tripeptide arginine-glycine-glycine, known as the RGG or GAR domain [10], [16], [17], [18], [19].

What is on the surface of cancer cells?

In addition, a number of changes in the biochemical characteristics of malignant cells’ surfaces have been observed. These include appearance of new surface antigens, proteoglycans, glycolipids, and mucins, and altered cell-cell and cell-extracellular matrix communication.

Where is nucleolin found?

the nucleolus
More than 90% of nucleolin is found in the nucleolus, nucleolin also has been found in the cytoplasm and on the cell surface. The shuttling of nucleolin between the nucleus, cytoplasm and plasmalemma is significant for normal nucleolin functions.

What does cellular cancer mean?

The Definition of Cancer When cells grow old or become damaged, they die, and new cells take their place. Sometimes this orderly process breaks down, and abnormal or damaged cells grow and multiply when they shouldn’t. These cells may form tumors, which are lumps of tissue.

What are 3 characteristics of cancer cells?

Cancer cells grow and divide at an abnormally rapid rate, are poorly differentiated, and have abnormal membranes, cytoskeletal proteins, and morphology. The abnormality in cells can be progressive with a slow transition from normal cells to benign tumors to malignant tumors.

How many nucleolus are in a human cell?

Although usually only one or two nucleoli can be seen, a diploid human cell has ten nucleolus organizer regions (NORs) and could have more nucleoli. Most often multiple NORs participate in each nucleolus.

What happens on a cellular level with cancer?

Cancer is a cell growth disease where cells undergo division many more times than normal. This makes the cells prone to replication errors—mistakes that occur during the copying of the DNA on the chromosomes that occurs in each cell division.

How Can cancer be treated at the cellular level?

Researchers are therefore working to develop a gentler treatment that ‘tricks’ the cancer cells, which would absorb a cytotoxin and therefore be destroyed, while healthy cells would remain unaffected. The most common treatments for cancer are radiation and chemotherapy.

How do tumors induce angiogenesis?

Tumor angiogenesis actually starts with tumor cells releasing molecules that send signals to surrounding normal host tissue. This signaling activates certain genes in the host tissue that, in turn, make proteins to encourage growth of new blood vessels.

What is the role of nucleolin in the pathogenesis of cancer?

The expression and localization of nucleolin is often abnormal in cancers, as the differential distribution of nucleolin in cancer can influence the carcinogenesis, proliferation, survival, and metastasis of cancer cells, leading to the cancer progression. Thus, nucleolin may be a novel and promising target for anti-cancer treatment.

Is nucleolin present in serum-starved cells?

No nucleolin band was detectable in the serum-starved cells, suggesting a lack of cell surface nucleolin expression. Nucleolin was also detected at the cell surface of growing MDA-MB-435 in FACS ® analysis using antibodies.

What do we need to know about nucleolin-targeted treatments?

Thus, analyzing the molecular activities of cell-surface nucleolin and the distribution of nucleolin in cells is requisite. Most of the studies of nucleolin-targeted treatments are still at the cellular and animal stages, and more clinical trials are required to verify the safety and effectivity of these therapies.

What is the role of nucleolin in angiogenesis?

Cell surface nucleolin expression is a novel angiogenesis marker. It provides a tool for studying tumor angiogenesis, including the contribution of precursor cells to this process, and for targeting drugs into tumors. The F3 peptide binds to and accumulates within both tumor endothelial cells and tumor cells in vivo ( Porkka et al., 2002 ).


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