What is the p2PSA test?
The p2PSA with two amino-acids is considered the most cancer-specific form. Prostate health index (PHI) is a mathematical formula of three biomarkers ([p2PSA/fPSA] × √tPSA) developed by Beckman Coulter, Inc. It has a high diagnostic accuracy rate and a better predictive value in patients harboring aggressive disease.
What does p2PSA mean?
Dots, squares and triangles indicate medians, respectively; whiskers stretch from the −95% confidence interval (CI) to the 95% CI for each age group. Abbreviations: tPSA, total prostate-specific antigen; fPSA, free prostate-specific antigen; p2PSA, [−2]proPSA; phi, prostate health index.
How is PHI test done?
The prostate health index (phi) is a formula that combines all 3 PSA forms (total PSA, free PSA, and p2PSA) into a single score. phi is calculated using the following formula: (p2PSA/free PSA) x square root of PSA.
What is a PHI blood test?
The Prostate Health Index (PHI) test is a diagnostic blood test that combines free and total PSA and the (-2) pro-PSA isoform (p2PSA). The PHI test is intended to reduce the number of unnecessary prostate biopsies in PSA-tested men.
How is p2PSA calculated?
The isoform p2PSA is a promising marker for PCa detection and compared to other isoforms, measurement of the p2PSA to free PSA (%p2PSA) and Prostate Health Index (Phi), which is calculated using the formula (p2PSA/fPSA × √tPSA) can better distinguish between PCa and non-PCa than tPSA and fPSA/tPSA (%fPSA)5,6,7.
What is a normal Phi?
A phi range between 0 and 26.9 corresponds to a probability of cancer of approximately 10%, while a phi score greater than 55 corresponds to a 50% probability of finding cancer upon biopsy.
Is Phi better than PSA?
Overall, phi provides superior diagnostic accuracy and better risk stratification than total PSA or %-free PSA as shown by ROC above the curve analysis. At a 95% sensitivity, using phi for risk stratification will result in an improvement in the number of men with benign disease who would be spared from a biopsy.
What is a good PHI score?
What does phi score mean?
| phi Range* | Probability of Cancer | 95% Confidence Interval |
|---|---|---|
| 0-26.9 | 9.8% | 5.2%-15.4% |
| 27.0-35.9 | 16.8% | 11.3%-22.2% |
| 36.0-54.9 | 33.3% | 26.8%-39.9% |
| 55.0+ | 50.1% | 39.8%-61.0% |
What is normal Phi?
The higher the score, the greater the probability of finding clinically significant disease. A phi range between 0 and 26.9 corresponds to a probability of cancer of approximately 10%, while a phi score greater than 55 corresponds to a 50% probability of finding cancer upon biopsy.
What is normal range of free PSA?
If you have a total PSA level between 4 and 10, doctors may test your blood for free PSA. A percent-free PSA above 25% is considered normal. Some doctors recommend that if you have a percent-free PSA of 18% or less you should have a prostate biopsy.
How can I make my prostate healthy?
5 Ways to Stay on Top of Prostate Health
- Eat a fresh, whole-foods diet. Fruits and vegetables are full of phytonutrients and antioxidants that help your cells stay healthy and replenished.
- Cut down or cut out alcohol and processed foods.
- Get more exercise.
- Restore your hormones.
- Get a prostate exam each year.
Is there a Phis Industry User Guide?
PHIS Industry User Guide This Public Health Inspection System (PHIS) Industry User Guide is designed for all industry representatives who produce and sell meat, poultry, and processed egg products regulated by USDA/FSIS. This guide provides detailed, role-based, step-by-step instructions on performing all industry actions within the PHIS.
What does Phis implementation mean for foreign government inspection certificates?
When PHIS implements on May 29, FSIS will no longer accept the foreign government’s guarantee to replace the non-compliant inspection certificate. FSIS will require replacement certificates in order to continue with the reinspection of the shipment.
What is the difference between pHis and FSIS reinspection?
Discrepancies between FSIS Form 9540-1 and the foreign inspection certificate must be rectified by the importer (or agent) before FSIS reinspection takes place just as it is currently. PHIS allows this process to take place electronically between the importer (or agent) and the FSIS import inspector.
What is eauth in the PHIS?
This guide provides detailed, role-based, step-by-step instructions on performing all industry actions within the PHIS. “eAuth” is the secure system that allows web-based access to USDA applications and services.