What is osteomyelitis?
Osteomyelitis – StatPearls – NCBI Bookshelf Bone infection is called osteomyelitis. It is an acute or chronic inflammatory process involving the bone and its structures secondary to infection with pyogenic organisms, including bacteria, fungi, and mycobacteria.
What are the treatment options for osteomyelitis?
Effective treatment of osteomyelitis involves a collaborative effort among various medical and surgical specialties. The two main aspects of therapy are surgical containment of the infection and prolonged antibiotics.
Why is the duration of treatment for long bone osteomyelitis prolonged?
The rationale behind the prolonged duration mostly stems from the limited bone penetration of most antimicrobials used in patients with NVO, the need for several weeks for bone to revascularize following surgery, and the limited experience derived from trials in pediatric patients with hematogenous long bone osteomyelitis [131–134].
What is the prevalence of vertebral osteomyelitis?
Vertebral osteomyelitis (additionally referred to as spinal osteomyelitis or spondylodiskitis) accounts for approximately 3% to 5% of all cases of osteomyelitis annually.[1] Vertebral osteomyelitis often has a nonspecific clinical presentation and thus delayed diagnosis up to several months is not uncommon.
What are the risk factors for osteomyelitis?
Risk factors. Your bones are normally resistant to infection, but this protection lessens as you get older. Other factors that can make your bones more vulnerable to osteomyelitis may include: A severe bone fracture or a deep puncture wound gives bacteria a route to enter your bone or nearby tissue.
Are oral fluoroquinolones effective in the treatment of Gram-negative osteomyelitis?
Oral fluoroquinolones and parenteral β-lactam agents can be used for treatment of gram-negative osteomyelitis, but increasing resistance has complicated management of these infections. Keywords: Osteomyelitis, Staphylococcus aureusosteomyelitis, methicillin-resistant Staphylococcus aureus, outpatient parenteral antibiotic therapy, fluoroquinolones
How do Lew Lew and Waldvogel classify osteomyelitis?
Lew and Waldvogel classified osteomyelitis based on the duration of illness as acute or chronic and by the mechanism of infection (either hematogenous or contiguous infection). Contiguous infection is further classified based on the presence or absence of associated vascular insufficiency.