What is the difference between etoposide and etoposide phosphate?

Etopophos (etoposide phosphate) can be given in a smaller amount of fluid and over a faster period of time compared to another form of the medicine (etoposide) since Etopophos (etoposide phosphate) is not associated with a large drop in blood pressure during injection.

What is etoposide FDA approved for?

On March 27, 2020, the Food and Drug Administration approved durvalumab (IMFINZI, AstraZeneca) in combination with etoposide and either carboplatin or cisplatin as first-line treatment of patients with extensive-stage small cell lung cancer (ES-SCLC).

How do you administer etoposide?

Etoposide should be given only by slow intravenous infusion (usually over a 30 to 60 minute period) since hypotension has been reported as a possible side effect of rapid intravenous injection. Injection site reactions may occur during administration of etoposide.

Who manufactures etoposide?

Among the largest etoposide manufacturers and suppliers are well-known pharmaceutical companies Pharmedic Laboratories, Teva, Sandoz, Accord Healthcare, and Fresenius Kabi. Etoposide suppliers and distributors market both generic and trade name formulations of the drug.

When do you use etoposide phosphate?

Etoposide phosphate is approved to be used with other drugs to treat:

1. Small cell lung cancer. It is used with cisplatin as first-line therapy.
2. Testicular cancer. It is used in patients who have already been treated with surgery, radiation therapy, or other chemotherapy and have not gotten better.

What is the mechanism of action of etoposide?

Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death.

When is etoposide used?

Etoposide is used in combination with other medications to treat a certain type of lung cancer (small cell lung cancer; SCLC). Etoposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.

How much does etoposide cost?

Etoposide is a generic prescription medication used, in combination with other medications, to treat small cell lung cancer. It comes in the form of an oral capsule and injection. The brand-name version of this drug is VePesid. The average retail price of Etoposide is about $73.22.

What class of chemo is etoposide?

Etoposide is in a class of medications known as podophyllotoxin derivatives. It works by slowing or stopping the growth of cancer cells in your body.

What are the side effects of etoposide?

Etoposide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea.
• vomiting.
• sores in the mouth and throat.
• stomach pain.
• diarrhea.
• constipation.
• loss of appetite or weight.
• unusual tiredness or weakness.

What is the antidote for etoposide?

These antidotes include isotonic (1/6 M) sodium thiosulfate for mechlorethamine (and optionally for cisplatin), hyaluronidase for the vinca alkaloids (and optionally for epipodophyllotoxins such as etoposide), and cooling with very topical DMSO and low dose hydrocortisone for the anthracyclines.

Which is given first carboplatin or etoposide?

Drug Administration Carboplatin: Administer by intravenous (IV) infusion over 30 to 60 minutes. Etoposide: Administer by IV infusion over 45 to 60 minutes.

Does etoposide need a filter?

Etoposide solutions of 0.1-0.4 mg/mL may be filtered through a 0.22 micron filter without damage to the filter; etoposide solutions of 0.2 mg/mL may be filtered through a 0.22 micron filter without significant loss of drug. Unopened vials of Etoposide Injection are stable for 24 months at room temperature (25°C).

Is etoposide protect from light?

Etoposide Injection USP should be stored at room temperature (15-30°C) and protected from light. Once multidose vial is punctured, Etoposide Injection USP should be protected from light and stored between 15-30 °C and used within 28 days.