What is saluretic effect?
(săl′yə-rĕt′ĭk) A drug that promotes excretion of salt in the urine. adj. Relating to or causing excretion of salt.
What is Saluretic index?
Saluretic index = urinary excretion of electrolyte of test group/urinary excretion of electrolyte of control group. Natriuretic index = urinary excretion of Na+/urinary excretion of K+ Ion quotient = urinary excretion of Cl-/sum of urinary excretion of Na+ and K+
What is the primary action of loop diuretics?
Loop diuretics are the most potent diuretics that reduce ECF, cardiac output, and blood pressure. The mechanism of action for loop diuretics like furosemide is by inhibiting the apical sodium/potassium/chloride transporter in the thick ascending limb of the loop of Henle.
What is the meaning of Saluretic?
: facilitating the urinary excretion of salt and especially of sodium ion a saluretic drug saluretic therapy.
What is Lipschitz test?
A method for testing diuretic activity in rats has been described by Lipschitz et al. ( 1943). The test is based. on water and sodium excretion in test animals and compared to rats treated with a high dose of urea. The “Lipschitz-value” is the quotient between excretion by test animals and excretion by the urea control …
What is the side effect of loop diuretics?
Common and shared side effects of the loop diuretics include dizziness, headache, gastrointestinal upset, hypernatremia, hypokalemia and dehydration.
How do loop diuretics affect potassium?
Because loop and thiazide diuretics increase sodium delivery to the distal segment of the distal tubule, this increases potassium loss (potentially causing hypokalemia) because the increase in distal tubular sodium concentration stimulates the aldosterone-sensitive sodium pump to increase sodium reabsorption in …
Does natriuresis lower BP?
Renal perfusion pressure can directly regulate sodium reabsorption in the proximal tubule. This acute pressure natriuresis response is a uniquely powerful means of stabilizing long-term blood pressure around a set point.
Which drug is used in experiment of diuretics?
A comparison was made with the standard diuretic drug furosemide, the diuretic effect observed after treatment with alcoholic extract of roots of Cissampelos pareira was found to be significant in terms of urinary output, sodium, potassium, chloride concentrations.
Is saluretic activity significant in all three groups?
It has been found that the saluretic activity was significant in all three groups when compared with control group. It has been found that the saluretic activity was significant in all three groups when compared with the control group as determined by one-way ANOVA followed by Bonferroni post hoc test.
Does epi potentiate the saluretic effects of amiloride?
This effect was not accompanied by a potentiation of the saluretic effects. On the other hand, when given EPI in combination with amiloride, a significant increase in Cl – excretion and maintenance of the potassium-sparing effects characteristic of this class of diuretics were detected.
Do loop diuretics have kaliuretic effects?
The kaliuretic effect of loop diuretics is smaller than that of the thiazides. After tau, e.g. over a 24 h period, kaliuresis was not correlated with natriuresis.