What is MIVACRON used for?

Mivacron is a highly selective, short-acting, non-depolarising neuromuscular blocking agent with a fast recovery profile. Mivacron is used as an adjunct to general anaesthesia to relax skeletal muscles and to facilitate tracheal intubation and mechanical ventilation in adults, children and infants 2 months and over.

What are non-depolarizing agents?

Nondepolarizing neuromuscular blockers are competitive acetylcholine (ACh) antagonists that bind directly to nicotinic receptors on the postsynaptic membrane, thus blocking the binding of ACh so the motor endplate cannot depolarize. [4] This leads to muscle paralysis.

Is mivacurium a Benzylisoquinoline?

Mivacurium belongs to a class of compounds that is commonly and erroneously referred to as “benzylisoquinolines;” mivacurium is in fact a bisbenzyltetrahydroisoquinolinium agent, often abbreviated to bbTHIQ.

What are non depolarizing muscle relaxants?

Nondepolarizing muscle relaxants bind ACh receptors but are incapable of inducing the conformational change necessary for ion channel opening. Because ACh is prevented from binding to its receptors, no end-plate potential develops. Neuromuscular blockade occurs even if only one α subunit is blocked.

Can you reverse mivacurium?

Conclusion: Recovery from a mivacurium chloride infusion is shorter by 3.6 minutes (margin of error +/- 3.3 minutes) when reversal with edrophonium/atropine is used. There is no difference in time to discharge from PACU and no evidence of differences in nausea and vomiting.

What drugs are used to reverse anesthesia?

Naloxone rapidly reverses sedation and respiratory depression due to previously administered narcotics, whereas flumazenil overturns the effects of midazolam on the central nervous system. Both agents are administered intravenously in repeated doses according to the patient’s response.

What is Nondepolarizing muscle relaxants?

Nondepolarizing muscle relaxants act as competitive antagonists. They bind to the ACh receptors but unable to induce ion channel openings. They prevent ACh from binding and thus end plate potentials do not develop.

What muscle relaxants release histamine?

Histamine release per se is predominantly found with the use of the benzylisoquinolines, d-tubocurarine, atracurium and mivacurium and the aminosteroid rapacuronium (I).

What is a Defasciculating agent?

A “defasciculating” dose of a nondepolarizing agent may reduce the duration and intensity of muscle fasciculations observed with the administration of succinylcholine (due to the stimulation of nicotinic acetylcholine receptors). The recommended dose is 10% of the paralyzing dose (eg, 0.01 mg/kg for vecuronium).

What is phase2 blockade?

Phase II blockade is thought to be secondary to repeated channel opening, causing distortion of the normal electrolyte balance and desensitizing the junctional membrane to further depolarization. It has some of the characteristics of a nondepolarizing blockade: Fade after tetanic or TOF stimulation.

What does non-depolarizing mean?

Can propofol be reversed?

Reversal agents exist for each class of drugs used in sedative procedures (unfortunately, propofol does not have a reversal agent). The current reversal agents, flumazenil for benzodiazepines and naloxone for opioids, work by binding to the same receptors that the sedative or opiate drug attaches to.