How common is lipoprotein lipase deficiency?
Most cases of familial LPL deficiency are identified during childhood, usually before the age of 10. In approximately 25 percent of patients, the disorder is identified during the first year of life. Some affected individuals may not be identified until adulthood.
What happens if lipase is missing?
Lipoprotein lipase deficiency is a genetic disorder in which a person has a defective gene for lipoprotein lipase, which leads to very high triglycerides, which in turn causes stomach pain and deposits of fat under the skin, and which can lead to problems with the pancreas and liver, which in turn can lead to diabetes.
Which of the following has initiated the helpline Kiran?
From places of great pain comes an unparalleled determination, and Raashi started a Change.org petition addressed to Health Minister Dr Harsh Vardhan to create a national helpline for suicide. And just over a year later, the Central government has created a helpline number (1800-599-0019) called ‘Kiran’.
What causes lipoprotein lipase deficiency?
Familial lipoprotein lipase deficiency is caused by a defective gene that is passed down through families. People with this condition lack an enzyme called lipoprotein lipase. Without this enzyme, the body cannot break down fat from digested food. Fat particles called chylomicrons build up in the blood.
What is lipoprotein lipase deficiency?
Familial lipoprotein lipase deficiency is an inherited condition that disrupts the normal breakdown of fats in the body, resulting in an increase of certain kinds of fats. People with familial lipoprotein lipase deficiency typically develop signs and symptoms before age 10, with one-quarter showing symptoms by age 1.
How do I report a mentally unstable person in India?
(2) Any private person who has reason to believe that any person is mentally ill and is not under proper care and control, or is ill-treated or neglected by any relative or other person having charge of such mentally ill person, may report the fact to the Magistrate within the local limits of whose jurisdiction the …
WHO launched the Mental Health Rehabilitation helpline named Kiran?
Thaawarchand Gehlot
The Centre on Monday launched a 24X7 toll free mental rehabilitation helpline for providing psychological support to people. The helpline ‘KIRAN’ (1800-599-0019) was launched by Union minister for social justice and empowerment Thaawarchand Gehlot.
What is lysosomal acid lipase deficiency?
Lysosomal acid lipase deficiency (LALD) is caused by mutations in the LIPA gene. LALD results from a deficiency of an enzyme, lysosomal acid lipase that is necessary for cholesterol metabolism. Patients with LALD often have a buildup of LDL and other lipids which are abnormally stored in the cells.
What is the main function of lipoprotein lipase?
Lipoprotein lipase plays a critical role in breaking down fat in the form of triglycerides, which are carried from various organs to the blood by molecules called lipoproteins.
How does lipoprotein lipase deficiency affect the body?
In people with familial lipoprotein lipase deficiency, increased fat levels can also cause neurological features, such as depression, memory loss, and mild intellectual decline (dementia). These problems are remedied when dietary fat levels normalize. This condition affects about 1 per million people worldwide.
How is familial lipoprotein lipase deficiency (LPL) diagnosed?
Measurement of lipoprotein lipase enzyme activity. Affected individuals. The diagnosis of familial lipoprotein lipase deficiency is confirmed by detection of low or absent LPL enzyme activity in an assay system that contains either normal plasma or apoprotein C-II (a cofactor of LPL) and excludes hepatic lipase (HL).
What is the prognosis of familial lipoprotein (LPL) deficiency?
Some individuals with familial LPL deficiency have developed premature atherosclerosis, which is characterized by thickening and obstruction of various blood vessels due to the accumulation of fatty material, potentially causing coronary heart disease or peripheral vascular disease.
Can gene therapy prevent pancreatitis in lipoprotein lipase deficiency?
Gene therapy coming of age – prevention of acute pancreatitis in lipoprotein lipase deficiency through alipogene tiparvovec. Eur Gastroenterol Hepatol Rev. 2010;6:48–53.