Why is precedex used in ICU?
Background. Dexmedetomidine produces sedation while maintaining a degree of arousability and may reduce the duration of mechanical ventilation and delirium among patients in the intensive care unit (ICU).
How effective is precedex?
A meta-analysis using the random effects model of two retrospective cohort studies revealed that the use of dexmedetomidine was associated with an average 37.9-hour reduction in overall hospital LOS (95% CI −60.41 hours to −15.46 hours; p-value 0.00).
Can propofol and precedex be taken together?
Conclusions: The combined use of propofol and dexmedetomidine provided cardiovascular stability with decreased adverse effects. Additionally, it led to a similar onset time of propofol and achieved higher satisfaction scores.
Can you Extubate on precedex?
Conclusion: Dexmedetomidine appears to maintain adequate sedation without hemodynamic instability or respiratory-drive depression, and thus may facilitate extubation in agitated difficult-to-wean patients; it therefore deserves further investigation toward this novel use.
Does precedex affect breathing?
The respiratory effects of dexmedetomidine markedly contrasted with those of remifentanil. When compared with baseline, during dexmedetomidine infusions, the respiratory rate significantly increased, and the overall apnea/hypopnea index significantly decreased.
Why is precedex bad?
Adverse effects of dexmedetomidine are mainly restricted to hemodynamic alterations. These include hypertension, bradycardia, and hypotension owing to pre- and postsynaptic α2-receptor activation, which causes vasoconstriction, vasodilatation, and reflex bradycardia (Ebert et al., 2000).
Why is propofol used in ICU?
Propofol has a number of properties that make it a potentially superior choice for sedation of intubated ICU patients. The rapid onset and offset of sedation with propofol, even after prolonged administration, allow for greater control over the level of sedation and more rapid weaning from mechanical ventilation.
How does precedex make you feel?
The most common adverse reactions to dexmedetomidine are hypertension, hypotension, nausea, bradycardia, hypoxia, and anemia.
How fast does precedex wear off?
Dexmedetomidine has a distribution half life of only 6 minutes and an elimination half life of 2 hours.
Why is Precedex bad?
Does propofol or Precedex cause more hypotension?
In a 2011 summary of Precedex safety data from RCTs analyzed by the the EMA (European FDA), the drug was found to be discontinued about 2% of the time for bradycardia and 1.5% of the time for hypotension, slightly more than propofol (0.4% brady and 1.1% hypotension) and significantly more than midazolam (0.3% and 0.3%) …