How quinoline is synthesis by Skraup?
The Skraup synthesis is a chemical reaction used to synthesize quinolines. In the archetypal Skraup reaction, aniline is heated with sulfuric acid, glycerol, and an oxidizing agent such as nitrobenzene to yield quinoline. In this example, nitrobenzene serves as both the solvent and the oxidizing agent.
What are quinoline derivatives?
Quinoline derivatives are considered broad-spectrum pharmacological compounds that exhibit a wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior.
What class of drug content is quinoline heterocycle?
aromatic heterocyclic series
quinoline, any of a class of organic compounds of the aromatic heterocyclic series characterized by a double-ring structure composed of a benzene and a pyridine ring fused at two adjacent carbon atoms.
Which of the ring in Isoquinoline gets easily reduced?
The hetero ring of quinoline is more easily reduced than the carbocyclic ring and selective reduction of the benzo-fused ring is seldom possible (however, see below). Isoquinoline can be completely reduced to cis- and trans-decahydroisoquinoline with hydrogen in acetic acid with a trace of sulfuric acid 〈48JA2617〉.
What is quinoline solution?
Quinoline is used in the manufacture of dyes, the preparation of hydroxyquinoline sulfate and niacin. It is also used as a solvent for resins and terpenes. Quinoline is mainly used as in the production of other specialty chemicals.
What is quinoline used to treat?
Antimalarial quinolines are used to prevent and treat malaria. During the blood stages of the life cycle of malaria parasite the parasite needs to degrade hemoglobin.
Is 6-methylquinoline a quinoline?
6-methylquinoline is a member of quinolines. Computed by Lexichem TK 2.7.0 (PubChem release 2021.05.07) Computed by InChI 1.0.6 (PubChem release 2021.05.07) LUYISICIYVKBTA-UHFFFAOYSA-N Computed by InChI 1.0.6 (PubChem release 2021.05.07) Computed by OEChem 2.3.0 (PubChem release 2021.05.07)
How to synthesize quinoline and quinoxaline using nickel catalyst?
A convenient and eco-friendly nickel-catalyzed synthesis of quinoline and quinoxaline via double dehydrogenative coupling starting from 2-aminobenzyl alcohol/1-phenylethanol and diamine/diol, respectively, operates at mild reaction temperatures. The inexpensive molecularly defined catalyst can easly be regenerated under aerobic/O 2 oxidation.
Is Skraup reaction possible in amines?
Currently, the Skraup reaction can be carried out in protic acid or in the presence of a Lewis acid. In case of unstable aromatic amine, a higher yield of quinoline has been reported.
What is quinoline synthesis from amino acids?
A practicable quinoline synthesis from aniline and two amino acids provides a wide range of quinolines with high efficiency and diversity including pharmaceutical derivatives, photochemical active compounds, and challenging scaffolds.