What is the source of IL-4?

What is the source of IL-4?

Interleukin-4 (IL-4) is a complex glycoprotein produced mostly by mast cells, basophils, a subset of activated T cells, eosinophils and neutrophils (Chomarat and Banchereau, 1997).

Is interleukin 13 inflammatory?

From these observations, it can be concluded that IL-13 is an antiinflammatory cytokine that plays a unique role in the induction and maintenance of IgE production and IgE-mediated allergic responses.

Is IL-4 pro-inflammatory or anti-inflammatory?

Interleukin-4 and IL-10 are pleiotropic anti-inflammatory cytokines that function mainly by suppressing the pro-inflammatory milieu. Several different immune cells that produce IL-4 are activated T cells, mast cells, basophils, eosinophils, and NKT cells (21, 22).

Is IL-4 pro inflammatory or anti-inflammatory?

Does interleukin 4 cause inflammation?

Where are interleukins found?

white blood cells
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells.

Where is interleukin 4 produced?

mast cells
Interleukin-4 (IL-4) is a complex glycoprotein produced mostly by mast cells, basophils, a subset of activated T cells, eosinophils and neutrophils (Chomarat and Banchereau, 1997).

Do polymorphisms of IL-4 and Il-4R predict thyroid cancer risk?

Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population. Blockade of IL-4Ralpha inhibits group 2 innate lymphoid cell responses in asthma patients.

What is the role of IL4R in the pathogenesis of breast cancer?

IL4R mediates enhanced glucose and glutamine metabolism in breast cancer cells. Receptor trafficking may play an important role for the regulation of IL-4R-mediated JAK/STAT signaling. Gene interactions were observed between IL4R and TNF-alpha genes in hand osteoarthritis patients.

Is IL4R a risk factor for glioblastoma?

Single nucleotide polymorphisms in IL4R gene is associated with the risk of adult glioma. The rs1801275 in IL-4R showed an increased risk of glioblastoma. An meta-analysis suggests that the IL-4Ralpha rs1801275 polymorphism is not a genetic predictor for glioma.

What is IL-4Rα?

IL-4 acts through the IL-4 receptor (IL-4R) that consists of two subunits, the α chain (IL-4Rα) and the γ chain (γc) [ 11, 12 ]. IL-4Rα is a component of both the IL-4 and the IL-13 receptor complexes [ 13 ].