Can quinolones cause tendonitis?
One well-described and serious adverse event associated with fluoroquinolones is tendinitis and tendon rupture. These injuries can result in long-term sequelae, including chronic pain and mobility restrictions, and may warrant surgical intervention.
Why do tendons rupture with quinolones?
Rupture of the Achilles tendon is a serious condition that often requires surgical treatment. Apart from several case reports and case series, one case-control study suggested that quinolones increase the risk of Achilles tendon rupture. Quinolones are antibacterial agents that act by inhibiting bacterial DNA gyrase.
How do fluoroquinolones affect tendons?
Tendinitis preceded rupture in 50% of 42 cases. Compared with the use of other antibiotics, the use of fluoroquinolones carries a 3.8-fold increased risk of Achilles tendinopathy.
Do all fluoroquinolones cause tendon rupture?
“In our study, fluoroquinolones as a class were not associated with the increased risk of tendon ruptures,” the researchers point out. “Neither ciprofloxacin nor moxifloxacin exhibited any risk for tendon ruptures. Levofloxacin did exhibit significant increased risk.
Is tendon damage from Levaquin permanent?
Fluoroquinolone medicines (which contain ciprofloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin, pefloxacin, prulifloxacin and rufloxacin) can cause long-lasting, disabling and potentially permanent side effects involving tendons, muscles, joints and the nervous system.
How often does levaquin cause tendon damage?
Achilles tendinopathy and tendon rupture are adverse side effects of levofloxacin treatment well recognised in the literature, but its presentation is very uncommon. The incidence rate for tendinopathy is 0.1% to 0.01%, and the incidence rate for tendon rupture is less than 0.01%.
When do side effects of Levaquin start?
SIDE EFFECTS: Drowsiness, dizziness, and weakness may occur. These side effects are more common during the first 4 weeks and usually lessen as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor.
Do statins affect tendons?
Statins have adverse effects on the tendon. Many studies have analyzed the relationship between atorvastatin and skeletal muscles. Atorvastatin administered after the surgical repair of a ruptured tendon appears to affect revascularization, collagenization, inflammatory cell infiltration, and collagen construction.
How common is tendon rupture with Levaquin?
How common is tendonitis with levofloxacin?
Can quinolones cause tendinitis?
Quinolones – A Tendoncy to Rupture. Tendon rupture and tendinitis are rare adverse events associated with the use of quinolone antibiotics. The Achilles tendon is most frequently involved but other sites can also be affected.
How do age-related tendinopathies differ from fluoroquinolone tendon problems?
“Patients who have age-related tendinopathies have small, discrete areas of internal damage to the tendon, whereas patients who experience tendinopathy from fluoroquinolone use tend to have more extensive abnormalities of the tendon,” Conti said. Thus, nonoperative treatments and recovery in these patients tend to take longer, he added.
Can fluoroquinolones cause tendon damage?
Fluoroquinolones and risk of tendon damage. Tendinopathy with fluoroquinolone use is rare, but since the drugs are used so often, clinicians who specialize in orthopedics and musculoskeletal injuries are likely to see patients with fluoroquinolone-associated tendinitis and tendon rupture, according to experts interviewed by LER.
What is the new classification of quinolones?
New Classification and Update on the Quinolone Antibiotics. With the increasing number of available quinolone antibiotics, prescribing these drugs has become a challenge. Compared with older quinolones such as norfloxacin (Noroxin) and ciprofloxacin (Cipro), the newer agents have an expanded antimicrobial spectrum and new indications.