What causes ICLs?
ICLs are formed when the two strands of DNA are covalently bound together through a linker molecule commonly known as a crosslinking agent. The first crosslinking agents to be identified were the nitrogen mustards developed during the warfare of the early twentieth century.
What causes interstrand crosslink?
In genetics, crosslinking of DNA occurs when various exogenous or endogenous agents react with two nucleotides of DNA, forming a covalent linkage between them. This crosslink can occur within the same strand (intrastrand) or between opposite strands of double-stranded DNA (interstrand).
What is an interstrand crosslink?
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the earliest, and are still the most widely used, forms of chemotherapeutic drug.
What are FA genes?
Fanconi anemia (FA) is a rare genetic disorder, in the category of inherited bone marrow failure syndromes. Half the patients are diagnosed prior to age 10, while about 10% are diagnosed as adults.
What does Interstrand mean?
Definition of interstrand : existing or occurring between two or more strands (as of DNA) interstrand covalent inter-strand conductance in multistrand cables.
What is ICL repair?
Interstrand DNA crosslinks (ICLs) are the link between Watson-Crick strands of DNAs with the covalent bond and prevent separation of DNA strands. Since the ICL lesion affects both strands of the DNA, the ICL repair is not simple.
What is RBC aplasia?
Pure red blood cell aplasia (PRCA) describes a type of anemia brought about by the marrow’s inability to produce these cells. An autoimmune disease, PRCA can result from drugs, viral infections, herpes, parvovirus B19 (fifth disease), hepatitis or HIV. Children can also be born with PRCA (Blackfan-Diamond syndrome).
What is Myelophthisic?
Myelophthisis is a form of bone marrow failure that results from the destruction of bone marrow precursor cells and their stroma, which nurture these cells to maturation and differentiation. (See Etiology.)
What is Interstand?
: occurring between, relating to, or involving two or more strands and especially strands of DNA interstrand cross-links.