What does CD138 negative mean?
Endometrial CD138 count appears to be a negative prognostic indicator for patients who have experienced previous embryo transfer failure – Fertility and Sterility.
What is plasma cell neoplasm?
Plasma cell neoplasms are diseases in which abnormal plasma cells or cells form tumors in the bones or soft tissues of the body. The plasma cells also make an antibody protein, called M protein, that is not needed by the body and does not help fight infection.
What is CD138 in multiple myeloma?
CD138 expression is a hallmark of plasma cells and multiple myeloma cells. However, decreased expression of CD138 is frequently observed in plasma cells of myeloma patients, although the clinical significance of this is unclear.
What is CD138 a marker of?
Within the hematopoietic system, CD138 is an excellent marker of plasmacytic differentiation. Based on its broad staining profile, CD138 reactivity for neoplastic cells is not a definitive marker for plasmacytic derivation, unless a hematolymphoid origin has been established.
What is a CD138 test?
CD138 is a protein present on plasma cells in the bone marrow, and on certain epithelial cells. The protein is useful to diagnose any neoplasms (tumors) growing in plasma cells. The test, called Immunohistochemistry, involves obtaining a tissue specimen from the patient, and staining it with the CD138 stain.
What does CD138 stain?
What is CD38 marker?
CD38 is a multi-functional transmembrane protein that is a lymphocyte receptor and a clinical marker for survival of patients with B-cell chronic lymphocytic leukemia (CLL) [1-5].
Can CD138 be used to isolate CD138+ plasma cells from plasma cell myeloma?
Introduction: The use of CD138 to isolate CD138(+) plasma cells (PCs) from plasma cell myeloma (PCM) patients’ bone marrow samples has been used extensively in myeloma research.
What is the best way to diagnose cd138-pcm?
Recognizing the presence of CD138 − PCM combined with morphology and other plasma cell markers, such as CD38 and MUM1, will be helpful for a correct diagnosis.
What are the CD38 and MUM1 expressed in neoplastic cells?
The neoplastic cells strongly expressed CD38 and MUM1, but were negative for CD138 by immunostains (panels C-E; original magnification ×40). Flow cytometry analysis showed that they expressed bright CD38 and monotypic cytoplasmic κ, but were negative for CD138, CD19, CD27, CD45, CD56, and CD117 (panels F-J).
What do we know about the CD138⁻ PCs?
We have characterised the CD138⁻ PCs as more immature and with a significantly higher proliferative potential. The current trend to ignore this more immature and proliferative subpopulation of malignant PCs may have serious implications when determining gene expression, classifications and drug sens …