What is the difference between trastuzumab and trastuzumab emtansine?
Trastuzumab alone stops growth of cancer cells by binding to the HER2 receptor, whereas trastuzumab emtansine undergoes receptor-mediated internalization into cells, is catabolized in lysosomes where DM1-containing catabolites are released and subsequently bind tubulin to cause mitotic arrest and cell death.
What is the success rate of trastuzumab emtansine?
The 3-year iDFS rate for those who were treated with T-DM1 was 97.8% (95% CI, 96.3%-99.3%; P < . 0001). The 3-year recurrence-free interval (RFI) rate was 99.2% (95% CI, 98.2%-100%).
What is ADO trastuzumab emtansine used for?
A drug used to treat certain patients with HER2-positive breast cancer that has already been treated with trastuzumab and a type of anticancer drug called a taxane. It is also being studied in the treatment of other types of cancer.
Can Herceptin cause indigestion?
eye problems such as dry eyes, watery eyes, blurred vision, redness of the eye or an infection. high blood pressure. indigestion which can cause bloating, feeling sick, discomfort and burping. swelling in the arms and legs due to a build up of fluid.
Do you lose your hair on Kadcyla?
Kadcyla doesn’t cause hair loss in most people who take the drug. And hair loss wasn’t reported as a side effect in Kadcyla’s prescribing information. In a trial that compared Kadcyla with another cancer treatment, hair loss did occur. But it wasn’t a common side effect with either drug.
Is Ado-trastuzumab emtansine chemo?
Kadcyla (ado-trastuzumab emtansine) is a new class of chemotherapy drug called an antibody-drug conjugate used to treat breast cancer.
Can Herceptin cause stomach pain?
Taking Herceptin may cause pain in the muscles or back. It could also cause pain in the upper abdomen (belly), or joints. In clinical studies, the following types of pain were reported in people taking Herceptin. Talk with your doctor if you have severe pain either during your infusion or between infusions.
Does Herceptin cause constipation?
Trastuzumab can commonly cause a rash that is usually not serious….Adjuvant Breast Cancer Studies.
| Adverse Reaction | One Year Herceptin (n = 1678) | Observation (n = 1708) |
|---|---|---|
| Nausea | 108 (6%) | 19 (1%) |
| Vomiting | 58 (3.5%) | 10 (0.6%) |
| Constipation | 33 (2%) | 17 (1%) |
| Dyspepsia | 30 (2%) | 9 (0.5%) |
What is trastuzumab emtansine?
Trastuzumab emtansine is a combination of the drug trastuzumab (also known by its brand name Herceptin) and a drug called emtansine. It is for HER2 positive breast cancer.
What is Kadcyla® (trastuzumab emtansine)?
Trastuzumab emtansine (Kadcyla®) is made of two different drugs joined together in one drug: Trastuzumab is a monoclonal antibody that works by ‘targeting’ specific proteins (receptors) on the surface of cells. Emtansine is a chemotherapy drug, which damages cancer cells.
How does trastuzumab kill cancer cells?
HER2 makes the cells grow and divide. Trastuzumab attaches to the HER2 receptor. When this happens it allows the emtansine to go into the cancer cell. Inside the cell emtansine becomes active and kills the cancer cell.
What is emtansine used to treat?
Emtansine is a chemotherapy drug, which damages cancer cells. Trastuzumab emtansine is used to treat HER2 positive breast cancers. It may be used in early breast cancer after surgery if there are still some cancer cells in the lymph nodes or breast.