What does P2Y12 receptor do?
The platelet P2Y12 receptor (P2Y12R) for adenosine 5’diphosphate (ADP) plays a central role in platelet function, hemostasis, and thrombosis. Patients with inherited P2Y12R defects display mild-to-moderate bleeding diatheses.
What type of receptor is P2Y12?
The P2Y12 receptor is a G-inhibitory-protein receptor in the platelet membrane, which is activated by ADP and results in the inhibition of adenylyl cyclase, thereby inducing platelet aggregation [33,34]. Moreover, the activation of P2Y12 receptor hinders the antiplatelet effects of prostacyclin.
What are P2Y inhibitors?
P2Y12 receptor blockers are another group of antiplatelet drugs. This group of drugs includes: clopidogrel, ticlopidine, ticagrelor, prasugrel, and cangrelor.
What does P2Y stand for?
P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) that belongs to the Gi class of a group of G protein-coupled (GPCR) purinergic receptors.
Is P2Y12 an ADP receptor?
The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y12 receptor antagonists that have proven therapeutic value.
What is a P2Y12 test?
Test results are in P2Y12 reaction units (PRU). This test measures the extent of platelet aggregation in the presence of P2Y12 inhibitor drugs such as clopidogrel (Plavix), prasugrel (Effient), ticagrelor (Brilinta) and ticlopidine (Ticlid).
Is Plavix P2Y12?
Clopidogrel (Plavix), a selective P2Y(12) receptor antagonist, is widely prescribed to reduce the risk of heart attack and stroke and acts via the inhibition of platelet aggregation.
What is a common side effect of antiplatelet medications?
Side effects
- headaches or dizziness.
- nausea.
- diarrhoea or constipation.
- indigestion (dyspepsia)
- stomach ache or abdominal pain.
- nosebleeds.
- increased bleeding (your blood taking longer to clot – for example, when you cut yourself), or easy bruising.
What keeps platelets from sticking together?
Antiplatelet drugs, such as aspirin, prevent blood cells called platelets from clumping together to form a clot. When you take a blood thinner, follow directions carefully. Blood thinners may interact with certain foods, medicines, vitamins, and alcohol.
What is an alternative drug to Plavix?
Brilinta has been marketed and studied as a more effective drug than Plavix. It has been shown to be a better drug for reducing rates of cardiovascular death and preventing heart attack or stroke.
What are the ADP receptors on platelets?
Human platelets possess 2 major ADP receptors: (1) the P2Y1 receptor, which initiates platelet shape change and ADP-induced aggregation through the mobilization of internal calcium stores, and (2) the P2Y12 receptor, which is coupled to adenylyl cyclase inhibition and is essential for a full aggregation response to ADP …
What are P2Y12 inhibitors?
Clopidogrel, a P2Y12 platelet inhibitor, is approved for the treatment of acute coronary syndrome and for patients who have had a recent MI, recent stroke, or established peripheral artery disease.
What are P2Y12 drugs?
Clopidogrel, a P2Y12 platelet inhibitor taken orally once a day, is approved for the treatment of acute coronary syndrome and for patients who have had a recent myocardial infarction, recent stroke, or established peripheral artery disease.
What is P2Y12 lab test?
VerifyNow PRU (P2Y12) Test. Testing is performed on blood collected in a 2 mL Greiner Bio-One partial fill sodium citrate tube with 3.2% sodium citrate which cannot be refrigerated or sent to the laboratory via pneumatic tube system. Testing is ideally performed within 4 hours of specimen collection.
What is a P2Y12 assay?
The VerifyNow P2Y12 assay measures platelet inhibition by substances known to specifically block the P2Y12 receptor. These compounds include the thienopyridine class of drugs, including clopidogrel and ticlopidine.