Does indole-3-carbinol reduce estrogen?
I3C decreases estrogen-driven luciferase activity. Treatment with genistein results in an even greater decrease. Treatment with the two phytochemicals reduces expression significantly more than would have been predicted if the effect of the two phytochemicals were additive, which indicates a clearly synergistic effect.
Does I3C increase estrogen?
Studies have shown that increasing the intake of vegetables of the cabbage family or taking I3C or DIM as a dietary supplement significantly increases the conversion of estrogen from cancer-producing forms to nontoxic breakdown products.
What is the benefits of taking indole-3-carbinol?
It is known to stimulate detoxifying enzymes in the gut and liver. Because diets high in these vegetables slow cancer growth in animals, I3C is thought to be a good candidate for cancer prevention. Lab studies suggest that I3C may have activity across various tumor types, or enhance activity of some chemotherapy drugs.
Does indole-3-carbinol have side effects?
Doses up to 400 mg daily have been used safely for 3-76 months. It can cause side effects such as skin rashes and diarrhea. In higher doses, indole-3-carbinol can cause balance problems, tremor, and nausea.
What is indole-3-carbinol?
Indole-3-carbinol is formed from a substance called glucobrassicin found in vegetables such as broccoli, Brussels sprouts, cabbage, collards, cauliflower, kale, mustard greens, turnips, and rutabagas. Indole-3-carbinol is formed when these vegetables are cut, chewed or cooked.
How much indole 3 carbinol is safe to take?
In general, Indole-3-Carbinol has been well tolerated by individuals at dosage ranges between 400 and 800 mg daily. Therefore, antacids, H2 blockers, and proton-pump inhibitors may impede its effectivenes. Indole 3 Carbinol Side Effects In very high doses, indole-3-carbinol can cause equilibrium imbalances, tremor and nausea.
Can indole-3-carbinol be used as a chemopreventive agent for breast cancer?
Studies indicate that Indole-3-Carbinol has potential value as a chemopreventive agent for breast cancer through its estrogen receptor modulating effect. There is also evidence to support the fact that I3C has a different mechanism of action than tamoxifen and that these two substances can be used synergistically.
How does indindole-3-carbinol eliminate estrogen?
Indole-3-Carbinol initiates a series of reactions in the body that culminates in the elimination of estrogen. Researchers have observed that metabolism of estrogen occurs via one of two pathways: The ‘harmful’ metabolic pathway, 16 alpha-hydroxylation, or the ‘beneficial’ metabolic pathway, 2-hydroxylation.