How much ephedrine is in Ephedra Sinica?
sinica, including one that was 98% ephedrine, one that had 10% norpseudoephedrine, and one that contained an average of 13% methylephedrine. We conclude that product inconsistency is common among some commercially available dietary supplements that contain ephedra alkaloids and caffeine.
What is the half life of ephedrine?
Pharmacokinetics. The duration of pressor and cardiac responses to ephedrine is 1 hour after intravenous administration of 10 to 25 mg Small quantities of ephedrine are metabolised in the liver, but the majority of ephedrine is excreted unchanged in the urine. The plasma half-life of ephedrine is 3 to 6 hours.
What should you not take with ephedrine?
Ephedrine may interact with other adrenalin-like drugs, MAO inhibitors, beta-blockers, blood pressure medicine, tricyclic antidepressants, diuretics (water pills), digoxin, atropine, theophylline, oxytocin, or St John’s wort. Tell your doctor all medications you are taking.
What is the major constituent in Ephedra sinica?
Ephedrine, the primary active constituent, has been studied alone and in combination with caffeine. The thermogenic properties of ephedrine are mainly due to its action as a sympathicomimetic compound.
What is Ephedra (ephedrine)?
Ephedra is sometimes marketed as a recreational drug “herbal ecstasy.” The FDA has announced that ephedra products marketed as recreational drugs are unapproved and that misbranded drugs can be taken by the authorities. How does it work? Ephedra contains a chemical called ephedrine. Ephedrine stimulates the heart, the lungs, and the nervous system.
Is ephedrine alkaloid-free?
Instead, they contain ephedra alkaloid-free herbal ephedra or ephedra extract, which do not contain ephedra alkaloids. Ephedrine is synthetic (produced in a lab) and not approved for use in weight loss pills. However, it’s in many over-the-counter decongestants and asthma relief products.
What is Ephedra sinica used for?
It has a long history of medicinal use in China and India to treat colds, fever, headaches, coughing, wheezing, and other conditions. The U.S. Food and Drug Administration (FDA) banned the sale of dietary supplements containing ephedrine alkaloids (stimulant compounds found in Ephedra sinica and some other plants) in the United States in 2004.
What are the long-term effects of ephedrine?
Weight loss. Ephedrine promotes modest short-term weight loss, specifically fat loss, but its long-term effects are unknown. In mice, ephedrine is known to stimulate thermogenesis in the brown adipose tissue, but because adult humans have only small amounts of brown fat, thermogenesis is assumed to take place mostly in the skeletal muscle.