What are drug-eluting beads?

What are drug-eluting beads?

Drug-eluting bead TACE is a drug delivery system that combines the local embolization of vasculature with the release of chemotherapy into adjacent tissue. 10,11. It is intended for use in the treatment of hypervascular tumours such as HCC.

How does DEB TACE work?

In conventional TACE there is a peak on the bloodstream of the chemotherapeutic agent right after the procedure [6, 7]. With DEB TACE there is a slow release of the chemotherapeutic agent into the hepatic tumor, limiting the systemic exposure of the drug and thus potentially reducing the occurrence of side effects.

What is a deb procedure?

During the DEB-TACE procedure, very small beads are mixed in with a chemotherapy drug, doxorubicin, and delivered to the tumor through an arterial catheter. The DEB-TACE procedure allows the treatment to be delivered directly into the liver.

What are doxorubicin beads used for?

It has been shown that the drug-eluting beads loaded with doxorubicin (DEBDOX) are effective for the treatment of hepatocellular carcinoma (HCC). However, the optimal safety and efficacy still remain to be established by using various bead sizes, doxorubicin doses, and the degree of stasis.

What is DC beads?

DC Bead™ is a loadable microsphere product primarily intended as an embolic agent for the local treatment of malignant hypervascularised tumour(s) in the liver and also intended to embolise the vessels supplying malignant colorectal cancer metastasised to the liver (mCRC).

How long do chemo beads last?

The beads will continue to release radiation over the course of two weeks following treatment, gradually decreasing to insignificant levels and with few side effects.

What is Transarterial Radioembolization?

Transarterial radioembolization (TARE) is a transcatheter intra-arterial procedure performed by the interventional radiologist for the treatment of primary and secondary hepatic cancers.

Who performs transarterial chemoembolization?

The TACE procedure is performed by a specialist, typically an interventional radiologist, who makes a very small incision in the groin to insert the catheter into the femoral artery.

How do you load doxorubicin LC beads?

When loading LC beads with powdered doxorubicin, a 50-mg vial of doxorubicin is reconstituted with 2 mL of sterile water. After removing saline from the LC bead vial, the 2 mL of reconstituted doxorubicin is then added to the LC bead vial and the vial is occasionally agitated to encourage mixing.

Is Radioembolization covered by Medicare?

Medicare coverage guidance is not available in the health plan’s service area for radioembolization for indications other than liver tumors, transarterial embolization (TAE) or transarterial chemoembolization (TACE). Therefore, the health plan’s medical policy is applicable.

What is a Drug Eluting Bead?

Core tip: Drug eluting beads are relatively new embolic agents that allow sustained release of chemotherapeutic agents in a localized fashion to the tumor. The advantage of DC bead transarterial chemoembolization (TACE) is a better combined ischemic and cytotoxic effect locally and less system toxicity when compared with conventional TACE.

Is transarterial chemoembolization the best treatment for hepatocellular carcinoma?

Transarterial chemoembolization (TACE) is a widely used standard treatment for patients with hepatocellular carcinoma (HCC) who are not suitable candidates for curative treatments. The rationale for TACE is that intra-arterial chemotherapy using lipiodol and chemotherapeutic agents, followed by sele …

What is the abbreviation for transarterial chemoembolization?

Transarterial chemoembolization with drug-eluting beads in hepatocellular carcinoma Transarterial chemoembolization (TACE) is a widely used standard treatment for patients with hepatocellular carcinoma (HCC) who are not suitable candidates for curative treatments.

How do chemotherapy beads work?

This does two things, first the small beads block the blood supply to the tumor depriving them of oxygen and nutrients; second, the beads slowly release the chemotherapy agent, allowing for a low systemic dose but maximizing the dose to the tumor. This allows for a high dose delivery to the tumor and a relatively low systemic dose.

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