What are the dosages for lovastatin?
Adults—At first, 20 milligrams (mg) once a day given with the evening meal. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg per day. Children 10 to 17 years of age—At first, 10 mg once a day given with the evening meal.
What is Mevastatin used for?
Mevastatin lowers hepatic production of cholesterol to reduce the risk of cardiovascular disease. Mevastatin competitively inhibits HMG-CoA reductase. This inhibition prevents the rate limiting step in cholesterol synthesis.
Why Mevastatin is a prodrug?
Mevastatin is a prodrug that is activated in vivo via hydrolysis of the lactone ring. The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with 10,000 times greater affinity than its natural substrate.
Can you overdose on lovastatin?
Lovastatin Overdose If you take too much lovastatin, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
What type of inhibitor is Mevastatin?
Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice.
What kind of inhibitor is Mevastatin with respect to Nadph?
Mevastatin (ML-236B) is a competitive inhibitor of HMG-Coenzyme A (HMG-CoA) reductase with a binding affinity 10,000 times greater than the HMG-CoA substrate itself.
Can lovastatin cause anxiety?
Psychiatric adverse effects, altering mood, personality, and behavior, sometimes arise in patients receiving statins. Statin psychiatric effects can include irritability/aggression, anxiety or depressed mood, violent ideation, sleep problems including nightmares, and possibly suicide attempt and completion.
Is lovastatin the same as Lipitor?
Lovastatin is the generic substitute for Mevacor, the granddaddy of all the statin cholesterol- lowering drugs. Lipitor has no generic at this time. In terms of potency, 10mg of Lipitor is roughly equivalent to 20mg of Zocor and 20mg of Mevacor.
Can you take lovastatin twice a day?
Lovastatin Overview It works by decreasing the amount of cholesterol made in the body. This medication comes as a tablet and an extended release tablet to take by mouth. The regular tablet usually is taken once or twice a day with meals. The extended release tablet usually is taken once a day at bedtime.
What is mevastatin?
Mevastatin is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.
What are the side effects of mevastatin and amphotericin B?
The metabolism of Mevastatin can be increased when combined with Amiodarone. The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Amphotericin B is combined with Mevastatin. The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Atorvastatin is combined with Mevastatin.
How does mevastatin bind to coenzyme A?
The bicyclic portion of mevastatin binds to the coenzyme A portion of the active site. With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.