What does a nucleolar ANA pattern mean?
This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren’s syndrome, Systemic Sclerosis, Polymyositis, and Rheumatoid Arthritis. Nucleolar: The ANA staining is seen around the nucleoles inside the nucleus.
How does Sjogren’s syndrome affect the pancreas?
Endoscopic retrograde pancreatograms demonstrated an abnormal pancreatic ductal configuration in 3 of 11 patients with Sjögren’s syndrome (27%), 2 of 9 with primary biliary cirrhosis (22%), and 3 of 4 with both diseases (75%). Only minimal changes in branches of the pancreatic duct were observed in the pancreatogram.
What ANA pattern is scleroderma?
Approximately 95% of people with systemic scleroderma have a positive antinuclear antibody (ANA) test, but so do people with other autoimmune diseases (97% of people with lupus, as an example). People with localized scleroderma usually have negative ANA.
Does Sjogren’s affect exocrine glands?
Sjögren’s syndrome is a chronic autoimmune process that primarily affects the exocrine glands and leads to their functional impairment.
Does lupus cause pancreatitis?
In 44% of the patients pancreatitis developed within 1 year of the diagnosis of lupus, and 84% had active lupus at the time of pancreatitis. Abdominal pain was the most frequent pancreatitis-related symptom (88%), followed by nausea or vomiting (67%).
Can you have 2 different ANA patterns?
The presence of more than one ANA pattern in a sample is referred to as a mixed ANA pattern. The most common of these is a mixture of Homogeneous and Speckled, but any combination is possible.
What disease causes nucleolar pattern?
For example, the nucleolar pattern is more commonly seen in the disease scleroderma. The speckled pattern is seen in many conditions and in people who do not have any autoimmune disease. Click to see full answer.
What does a nucleolar Ana pattern mean?
Another pattern, known as a nucleolar pattern, is common in people with scleroderma. In fact, only 2% of people with lupus will have a negative ANA. People with lupus who have a negative ANA test may have anti-Ro/SSA or antiphospholipid antibodies. Additionally, what does a smooth ANA pattern mean?
What are the common disorders of the pancreas?
Common Disorders of the Pancreas. There are a variety of disorders of the pancreas including acute pancreatitis, chronic pancreatitis, hereditary pancreatitis, and pancreatic cancer. The evaluation of pancreatic diseases can be difficult due to the inaccessibility of the pancreas. There are multiple methods to evaluate the pancreas.
What is nucleolar staining of antinuclear antibodies in systemic sclerosis (SSc)?
Nucleolar staining of antinuclear antibodies (ANAs) is not exclusive to patients suffering systemic sclerosis (SSc) since it can occur in other autoimmune diseases, such as systemic lupus erythematosus (SLE). The nucleolar ANA pattern presents a low incidence in patients with SLE, with less than 9% reported in some studies.