What is CXCL9 test?
The CXCL9/CXCR3 receptor regulates immune cell migration, differentiation, and activation. Immune reactivity occurs through recruitment of immune cells, such as cytotoxic lymphocytes (CTLs), natural killer (NK) cells, NKT cells, and macrophages.
What cells produce CXCL9?
CXCL9, -10, -11 are mainly secreted by monocytes, endothelial cells, fibroblasts, and cancer cells in response to IFN-γ, which are synergistically enhanced by TNF-alpha. [9, 10] CXCR3 is a receptor preferentially expressed on the surface of monocytes, T cells, NK cells, dendritic cells, and cancer cells.
What cells express CXCL10?
CXCL10 (interferon-γ-inducible protein 10, previously called IP-10) was initially discovered as a chemokine which is induced by interferon (IFN)-γ and is produced by a wide range of cell types including monocytes [15], neutrophils [16], endothelial cells [17], keratinocytes [18], fibroblasts [19], mesenchymal cells [20 …
Do neutrophils produce chemokines?
Chemokines produced by neutrophils in inflamed tissues amplify and polarize the immune response, and the expression of CCR7 by activated neutrophils promotes their migration to LN, where they can directly act as APC.
What is MIP3A?
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils.
What is Gene CXCL10?
CXCL10 (C-X-C Motif Chemokine Ligand 10) is a Protein Coding gene. Diseases associated with CXCL10 include Periapical Periodontitis and Viral Encephalitis. Among its related pathways are ERK Signaling and Cytokine Signaling in Immune system.
What produces il8?
4.2. IL-8 (CXCL-8) is a chemokine of the CXC family and it is actively produced by monocytes/macrophages and other cell types like endothelial cells, epithelial cells and airways smooth muscle cells [189,190].
What is the pathophysiology of CXCL9?
CXCL9, also known as monokine induced by gamma interferon (MIG), is located on human chromosome 4, and is induced by IFN-γ but not by IFN-α/β. CXCL10 and CXCL11 are also located on human chromosome 4. CXCL9 predominantly mediates lymphocytic infiltration to the focal sites and suppresses tumor growth.
What is CXCL9 10 10 11?
CXCL9, -10, -11 are ELR-negative CXC chemokines that generally attenuate angiogenesis, leading to an anti-tumor effect. Interestingly, some reports show that CXCL9, -10, -11 increase tumor proliferation and metastases [7].
Are CXCL9 and cxcr3a anti-tumor?
CXCL9, -10, -11 are ELR-negative CXC chemokines that generally attenuate angiogenesis, leading to an anti-tumor effect. Interestingly, some reports show that CXCL9, -10, -11 increase tumor proliferation and metastases [7]. This may be due to the different effects of the ligands on the variants of CXCR3 (CXCR3A, CXCR3B and CXCR3-alt).
What is the CXCL9 axis used for?
CXCL9, CXCL10, CXCL11/ CXCR3 axis, a target for cancer treatment. The CXCL9, -10, -11/ CXCR3 axis is a promising target for drug development by activating the paracrine axis, and inhibiting the autocrine axis.