What is pathophysiology of rheumatic fever?
Pathophysiology. Rheumatic fever is a systemic disease affecting the connective tissue around arterioles, and can occur after an untreated strep throat infection, specifically due to group A streptococcus (GAS), Streptococcus pyogenes.
What is the mechanism by which acute rheumatic fever occurs?
Acute rheumatic fever (ARF) results from the body’s autoimmune response to a throat infection caused by Streptococcus pyogenes, also known as the group A Streptococcus bacteria.
What is the anatomy of rheumatic fever?
rheumatic fever, inflammatory disease of the heart, joints, central nervous system, and subcutaneous tissues that develops after a throat infection with group A beta-hemolytic Streptococcus bacteria, including untreated scarlet fever or strep throat.
What murmur is associated with rheumatic fever?
The Carey Coombs Murmur occurs during acute rheumatic fever. Mitral valvulitis can occur causing thickening of the leaflets. A murmur is created by increased blood flow across the thickened mitral valve.
Which valve is affected by rheumatic fever?
Rheumatic fever is a bacterial infection that can cause problems with the heart’s aortic and mitral valves.
What is the process of pathophysiology?
Pathophysiology (consisting of the Greek origin words “pathos” = suffering; “physis” = nature, origin; and “logos” = “the study of”) refers to the study of abnormal changes in body functions that are the causes, consequences, or concomitants of disease processes.
What is tuberculosis pathophysiology?
Pathogenesis of TB. Infection occurs when a person inhales droplet nuclei containing tubercle bacilli that reach the alveoli of the lungs. These tubercle bacilli are ingested by alveolar macrophages; the majority of these bacilli are destroyed or inhibited.
Which valves are commonly affected by rheumatic fever?
Although rheumatic fever can affect any heart valve, it most commonly affects the mitral valve which lies between the two chambers of the left side of the heart. The damage can cause valve stenosis, valve regurgitation and/or damage to the heart muscle.
What are the differential diagnoses for rheumatic fever?
The differential diagnosis of acute rheumatic fever is broad due to the various symptoms of the disease. There is no definitive diagnostic test for acute rheumatic fever. A clinical diagnosis of acute rheumatic fever should be made using the Jones Criteria.
Which bacterial organism is responsible for rheumatic fever?
Rheumatic fever. Rheumatic fever is a disease that may develop after an infection with group A streptococcus bacteria (such as strep throat or scarlet fever). It can cause severe illness in the heart, joints, skin, and brain.
Why does rheumatic fever damage the heart?
Rheumatic fever is a complication of untreated strep throat (caused by a group A streptococcal infection). Rheumatic fever can damage body tissues by causing them to swell, but its greatest danger lies in the damage it can do to your heart. More than half of the time, rheumatic fever leads to scarring of the heart’s valves.