What is the pathophysiology of Henoch-Schonlein purpura?

What is the pathophysiology of Henoch-Schönlein purpura?

The pathophysiology of Henoch-Schönlein purpura is not fully understood; however, IgA plays a significant role. IgA-antibody immune complexes caused by antigenic exposure from an infection or medication deposit in the small vessels (usually capillaries) of the skin, joints, kidneys, and gastrointestinal tract.

What is the difference between vasculitis and HSP?

Using that nomenclature, HSP is now referred to as IgA vasculitis (Henoch–Schönlein) and is defined as vasculitis, with IgA1-dominant immune deposits affecting small vessels (predominantly capillaries, venules, or arterioles); it often involves the skin and the gastrointestinal tract, and frequently causes arthritis.

What does HSP rash look like?

The main symptom of HSP is a rash of raised red or purple spots. The spots look like small bruises or blood spots.

Does Henoch-Schönlein purpura have thrombocytopenia?

Henoch-Schönlein purpura is an acute, systemic, immune complex-mediated, leukocytoclastic vasculitis. It is characterized by a triad of palpable purpura (without thrombocytopenia), abdominal pain, and arthritis. Most patients have an antecedent upper respiratory illness.

Is Henoch Schonlein Purpura an autoimmune disease?

HSP is an autoimmune disease that is often triggered by an upper respiratory infection. Symptoms include a rash caused by bleeding under the skin, arthritis, belly pain, and kidney disease. Most children recover fully. But some children may have kidney problems.

What causes adult Hyperstatic?

Nearly half the people who have Henoch-Schonlein purpura developed it after an upper respiratory infection, such as a cold. Other triggers include chickenpox, strep throat, measles, hepatitis, certain medications, food, insect bites and exposure to cold weather.

Does Henoch-Schonlein purpura go away?

Henoch-Schonlein purpura usually goes away on its own within a month with no lasting ill effects. Rest, plenty of fluids and over-the-counter pain relievers may help with symptoms.

What is Henoch–Schönlein purpura?

What is Henoch–Schönlein purpura? Henoch–Schönlein purpura (HSP) is a form of leukocytoclastic or small-vessel vasculitis, most often observed in children. It is sometimes called anaphylactoid purpura. HSP results from inflammation of the small blood vessels in the skin and various other tissues within the body.

What is henhenoch-Schonlein purpura (IgA vasculitis)?

Henoch-Schonlein purpura (also known as IgA vasculitis) is a disorder that causes the small blood vessels in your skin, joints, intestines and kidneys to become inflamed and bleed. The most striking feature of this form of vasculitis is a purplish rash, typically on the lower legs and buttocks.

Can Henoch-Schönlein purpura (HSP) cause kidney disease?

In a small minority of cases, HSP can cause severe kidney or bowel disease. Dr. William Heberden, a London physician, described the first cases of Henoch-Schönlein purpura (HSP) in 1801.

What are the signs and symptoms of henhenoch-Schönlein purpura?

Henoch-Schönlein purpura is an IgA-mediated immune vasculitis involving the small vessels of the joints, kidneys, gastrointestinal (GI) tract, skin, and less commonly, the central nervous system and lungs. Patients with this disorder typically present with gastrointestinal complaints, palpable purpura, arthralgias, and renal involvement.

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