What is the side effect of plx4032?

What is the side effect of plx4032?

Table 1 presents adverse reactions reported in at least 10% of unresectable or metastatic melanoma patients treated with ZELBORAF….Erdheim-Chester Disease (ECD)

Trial 4: Patients with ECD
Body System Adverse Reactions n=22
Diarrhea 50
Nausea 32
Vomiting 23

What are the side effects of Trametinib?

More common

  • Burning, itching, and pain in hairy areas, pus at the root of the hair.
  • canker sores.
  • change in taste.
  • dry eyes.
  • dry skin.
  • itching, pain, redness, swelling, tenderness, or warmth on the skin.
  • loosening of the fingernails.
  • loss of taste.

What is Cotellic used for?

COTELLIC is a prescription medicine that is used with the medicine ZELBORAF, to treat a type of skin cancer called melanoma that has spread to other parts of the body or cannot be removed by surgery, and that has a certain type of abnormal “BRAF” gene.

How much does Cobimetinib cost?

The cost for Cotellic oral tablet 20 mg is around $7,323 for a supply of 63 tablets, depending on the pharmacy you visit.

What does PLX4032 mean?

Vemurafenib (PLX4032, RG7204, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay. 10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold. Vemurafenib (PLX4032, RG7204) induces autophagy. Nature, 2014, 3;508 (7494):118-22.

How does PLX4032 work in melanoma?

“PLX4032, a Selective BRAF (V600E) Kinase Inhibitor, Activates the ERK Pathway and Enhances Cell Migration and Proliferation of BRAF (WT) Melanoma Cells”. Pigment Cell Melanoma Res. 23 (2): 190–200. doi: 10.1111/j.1755-148X.2010.00685.x.

How does PLX4032 work in BRAF cells?

PLX4032 inhibits ERK signaling output in mutant BRAF cells, whereas it transiently activates the expression of these genes in tumor cells with wild-type RAF. Thus, PLX4032 inhibits ERK signaling output in a mutant BRAF-selective manner.

What is the difference between PLX4032 and MEK inhibitors?

In BRAF(V600E) tumor cells, MEK and RAF inhibitors affect the expression of a common set of genes. PLX4032 inhibits ERK signaling output in mutant BRAF cells, whereas it transiently activates the expression of these genes in tumor cells with wild-type RAF.

Begin typing your search term above and press enter to search. Press ESC to cancel.

Back To Top