What Wnt cancer?

What Wnt cancer?

Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities.

What is TCF7L2?

Function. TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions within the cell. It is a member of the TCF family that can form a bipartite transcription factor (β-catenin/TCF) alongside β-catenin.

Is wnt a tumor suppressor?

These studies are consistent with the Wnt pathway acting as a tumor suppressor in retinoblastoma and suggest that loss of Wnt signaling is tumorigenic in the retina.

How do I activate Wnt signal?

To activate Wnt signaling, one can add Wnt protein, either in a purified form or as conditioned medium to cells. Cells producing active Wnt can be obtained from the ATCC (see also the reagents page). Active Wnt protein can be obtained from several companies.

What is a possible function of TCF7L2 gene?

Tcf7l2 plays a role in regulating glucose tolerance, suggesting that overexpression of this gene is associated with increased risk of T2D. TCF7L2 polymorphism was associated with higher fasting proinsulin at baseline, higher baseline proinsulin:insulin ratio and increased proinsulin:insulin ratio in type 2 diabetes.

How is Wnt activated?

All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the Dishevelled protein inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part by the SPATS1 gene.

Is Wnt a proto oncogene?

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 (INT1) gene. The WNT gene family consists of structurally related genes that encode secreted signaling proteins.

Does transcription factor 7 like 2 (TCF7L2) play a role in diabetes mellitus?

Studied the role of transcription factor 7 like 2 (TCF7L2) single nucleotide polymorphisms (SNPs) in genetic predisposition to diabetes mellitus type 2. rs7074440 was identified as a candidate functional SNP linked with genome-wide association studies-lead SNP for type 2 diabetes, which directly binds to C-FOS to alter TCF7L2 gene expression.

What does TCF7L2 stand for?

TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization. Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan. Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm.

Does TCF4 (TCF7L2) induce enzalutamide resistance in prostate cancer?

The authors found TCF7L2 and EGR1 (early growth response 1) are important transcription factors for LCN2 (lipocalin 2)expression via an ERK1/2-dependent pathway in esophageal squamous cell carcinoma. the current results indicate that TCF4 (TCF7L2) induces enzalutamide resistance via NED in prostate cancer (CaP).

Are TCF7L2 SNPs associated with breast cancer risk in northwest Chinese Han?

The study found that TCF7L2 SNPs (rs1225404 and rs7003146) might be associated with breast cancer risk in Northwest Chinese Han populations. These findings further support the hypothesis that TCF7L2 gene variation contributes to diabetogenesis in a subset of young people with Type 1 diabetes.