Why was phenylpropanolamine taken off the market?

Why was phenylpropanolamine taken off the market?

Phenylpropanolamine has been voluntarily removed from the market in the United States by its manufactures because of concerns raised about its ability to precipitate a stroke when used, or perhaps abused, as an appetite suppressant Kernan et al (2000).

Is phenylpropanolamine still used?

In the United States, PPA is no longer sold due to an increased risk of haemorrhagic stroke. In a few countries in Europe, however, it is still available either by prescription or sometimes over-the-counter.

Is phenylpropanolamine banned by the FDA?

FDA today issued a public health advisory concerning the risk of hemorrhagic stroke, or bleeding into the brain, associated with phenylpropanolamine hydrochloride. The committee reviewed Yale’s Hemorrhagic Stroke Project results and concluded that phenylpropanolamine cannot be considered to be safe for continued use.

Why was PPA banned?

WASHINGTON–The Food and Drug Administration asked manufacturers to voluntarily stop selling drugs containing phenylpropanolamine (PPA) on Monday after the agency reported that there was a link between hemorrhagic strokes among young women and use of the drug.

What class of drug is phenylpropanolamine?

Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant.

Can you buy phenylpropanolamine over the counter?

It is available in nonprescription products alone and in combination with other nonprescription drugs, to treat symptoms of allergy , colds, and upper respiratory infections. Phenylpropanolamine is also used as an adjunct to calorie restriction in short-term weight loss.

What are the side effects of phenylpropanolamine?

COMMON side effects

  • constipation.
  • drowsiness.
  • inducing of a relaxed easy state.
  • excessive sweating.
  • nausea.
  • vomiting.
  • stomach cramps.
  • an increase in the thickness of lung secretions.

What is the FDA doing about phenylpropanolamine?

The Food and Drug Administration (FDA) is taking steps to remove phenylpropanolamine (PPA) from all drug products and has requested that all drug companies discontinue marketing products containing PPA. In addition, FDA has issued a public health advisory concerning phenylpropanolamine.

Does phenylpropanolamine cause hemorrhagic stroke?

FDA believes that although the risk of hemorrhagic stroke is very low, even with phenylpropanolamine use, the conditions for which these products are used do not appear to warrant an increased risk of this serious event from using this drug.

Where can I find information about phenylpropanolamine (ppg)?

Information about the history of phenylpropanolamine, the Public Health Advisory, and the stroke study results can be found on the FDA website at: www.fda.gov/cder/drug/infopage/ppa/default.htm.

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