What is the pKa of imidazole?

What is the pKa of imidazole?

Imidazole is an important intracellular buffer because it is a building block for proteins and enzymes and because it has a pKa (at 37°C) of 6.8 (close to intracellular pH).

What does imidazole do in a reaction?

Imidazole is a base and an excellent nucleophile. It reacts at the NH nitrogen, attacking alkylating and acylating compounds.

How do you synthesis imidazole?

The Van Leusen Imidazole Synthesis allows the preparation of imidazoles from aldimines by reaction with tosylmethyl isocyanide (TosMIC). The reaction has later been expanded to a two-step synthesis in which the aldimine is generated in situ: the Van Leusen Three-Component Reaction (vL-3CR).

Which reaction is used for synthesis of oxazole?

The cyanohydrin itself is derived from a separate aldehyde. The reactants of the oxazole synthesis itself, the cyanohydrin of an aldehyde and the other aldehyde itself, are usually present in equimolar amounts….

Fischer oxazole synthesis
Reaction type Ring forming reaction

What is the pH of imidazole?

Imidazole can be used to prepare buffers in the pH range of 6.2-7.8 at 25° C.

What is the reaction conditions of Chichibabin reaction?

Dimerization is a side reaction that can occur. When heated in xylene and sodium amide at atmospheric pressure, the substrate 4-tert-butylpyridine produces 89% of the dimer product (4,4′-di-tert-butyl-2,2′-bipyridine) and only 11% of the aminated Chichibabin product (2-amino-4-tert-butylpyridine).

What is the molecular formula of quinoline?


What is imidazole hydrochloride?

Imidazole hydrochloride is the hydrochloride salt preparation of the ubiquitous heterocycle imidazole. Solubility : Soluble in methanol (50 mg/ml), and water (~50 mg/ml). Melting Point : 158-161° C (lit.)

Which drug contains imidazole nucleus?

Many imidazole-based derivatives have been marketed as antifungal drugs such as ketoconazole (1), miconazole (2), clotrimazole (3), tioconazole (4), econazole (5), tinidazole (6), enilconazole/imazalil (7), parconazole (8), eberconazole (9), lanoconazole (10), fenticonazole (11), bifonazole (12), sulconazole (13).

How are imidazole derivatives synthesized?

Several functionalized imidazole derivatives exhibit pharmacological property and play important roles in biochemical processes. The most common method for the synthesis of 2,4,5-trisubstituted imidazoles is the reaction of benzils with aldehydes in the presence of ammonium acetate as the source of nitrogen.

What is a copper-catalyzed N-arylation reaction of imidazole?

A copper-catalyzed N -arylation reaction of imidazole proceeds under very mild conditions in the absence of additional ligand. This protocol tolerates an array of thermally sensitive functional groups, but also achieves high chemoselectivity. L. Zhu, G. Li, L. Luo, P. Guo, J. Lan, J.

How does imidazole act as a Brønsted base?

Imidazole also acts as a Brønsted base and can bind to anions in the form of the imidazolium group by a combination of hydrogen-bonding and electrostatic interactions. A. Mahmood, R. Zou, in Comprehensive Supramolecular Chemistry II, 2017

What is the role of urea-zncl2 in the formation of imidazoles?

The low-melting mixture urea-ZnCl 2 as reaction medium efficiently catalyzes the formation of imidazoles from a dicarbonyl compound, ammonium acetate, and an aromatic aldehyde to provide a broad range of triaryl-1 H -imidazoles or 2-aryl-1 H -phenanthro [9,10- d ]imidazoles in very good yields.

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